海南医学院学报2018，Vol.24Issue(2)：250-253,4.DOI:10.13210/j.cnki.jhmu.20180105.006
右美托咪定预处理对非小细胞肺癌手术患者术后免疫功能及炎症应激反应的影响
Effect of dexmedetomidine pretreatment on postoperative immune function and inflammatory stress response in patients with non-small cell lung cancer surgery
摘要
Abstract
Objective:To study the effect of dexmedetomidine pretreatment on postoperative immune function and inflammatory stress response in patients with non-small cell lung cancer surgery.Methods:Patients with non-small cell lung cancer who underwent radical operation for lung cancer in Xi'an Aerospace General Hospital between August 2014 and September 2017 were selected and randomly divided into the Dex group who received dexmedetomidine pretreatment combined with general anesthesia and the control group who received routine general anesthesia.The same day after surgery and 3 d after surgery,the peripheral blood was collected respectively to determine the contents of immune cells and the serum was collected respectively to determine the contents of inflammatory stress response indexes.Results:The same day after surgery and 3 d after surgery,CD3+ CD4+T cell,CD3+ CD8+T cell and CD16+ CD56+ NK cell contents in peripheral blood of Dex group were significantly higher than those of control group whereas CD11b+ CD15+ CD33+ CD14 G-MDSC,CD11b+ CD15 CD33+ CD14+ MMDSC and CD4+CD25+ CD127lowTreg contents in peripheral blood as well as TNF-α,SAA,CRP,IL-8,IL-10,Cor,Ins,NE,E and AT-Ⅱ contents in serum were significantly lower than those of control group.Conclusion:Dexmedetomidine pretreatment can improve the immune function and inhibit the inflammatory stress response in patients with non-small cell lung cancer surgery.关键词
非小细胞肺癌/肺癌根治术/右美托咪定/免疫功能/炎症应激反应Key words
Non-small cell lung cancer/Radical operation for lung cancer/Dexmedetomidine/Immune function/Inflammatory stress response分类
医药卫生引用本文复制引用
贺军阳..右美托咪定预处理对非小细胞肺癌手术患者术后免疫功能及炎症应激反应的影响[J].海南医学院学报,2018,24(2):250-253,4.基金项目
陕西省自然科学研究基础资助项目(2010IM3021)This study was supported by Foundation Support Project of Shaanxi Natural Science Research (grant No.2010IM3021). （2010IM3021）
