海南医学院学报2018，Vol.24Issue(2)：262-265,4.DOI:10.13210/j.cnki.jhmu.20180105.017
宫颈癌超声弹性成像参数与癌细胞恶性生物学行为的相关性研究
The correlation between the ultrasonic elastography parameters of cervical cancer and the malignant biological behavior of cancer cells
摘要
Abstract
Objective:To investigate the correlation between the ultrasonic elastography parameters of cervical cancer and the malignant biological behavior of cancer cells.Methods:A total of 180 patients with cervical cancer who were diagnosed and treated with radical operation in this hospital were selected as research subjects,and the cervical cancer tissue and adjacent tissue samples were collected during operation and stored in liquid nitrogen tanks.The ultrasonic elastography strain ratio of cervical cancer and adjacent tissues was detected before operation,and the differences in the expression of genes associated with proliferation,invasion and autophagy were compared.Pearson test was used to evaluate the correlation between the cervicalcancer strain ratio and the malignant biological behavior of cancer cells.Results:The strain ratio level of cervical cancer tissue was higher than that of adjacent tissue (P＜0.05);proliferation-related genes AEG-1,TRAF6 and FoxM1 mRNA expression were higher than those in adjacent tissue (P ＜0.05) whereas SFRP2,MST1 and Bmi-1 mRNA expression were lower than those in adjacent tissue (P ＜0.05);invasion-related genes ILK,Sox2,Twist,YB-1 and Rab1 1 mRNA expression were higher than those in adjacent tissue (P＜0.05);autophagy-related genes ARHI,Beclin1,PULK and PI3KC3 mRNA expression were lower than those in adjacent tissue (P＜0.05).Conclusions..Ultrasonic strain ratio level of cervical cancer is closely related to the proliferation,invasion and autophagy activity of cancer cells,and is positively correlated with the overall malignancy of the tumor.关键词
宫颈癌超声弹性成像/增殖/侵袭/自噬Key words
Ultrasonic elastography of cervical cancer/Proliferation/Invasion/Autophagy分类
医药卫生引用本文复制引用
马珊..宫颈癌超声弹性成像参数与癌细胞恶性生物学行为的相关性研究[J].海南医学院学报,2018,24(2):262-265,4.基金项目
山东省自然科学基金项目(81470127)This study was supported by Shandong Provincial Natural Science Foundation Project (Grant No.81470127). （81470127）
