海南医学院学报2018，Vol.24Issue(3)：327-330,4.DOI:10.13210/j.cnki.jhmu.20180117.007
高渗盐水+沙丁胺醇雾化吸入对毛细支气管炎患儿炎症应激反应的影响
Effect of inhalation of hypertonic saline combined with salbutamol aerosol inhalation on in-flammatory stress response in children with bronchiolitis
摘要
Abstract
Objective:To investigate the effect of inhalation of hypertonic saline and salbutamol aerosol inhalation on in-flammatory stress response in children with bronchiolitis.Methods:92 children with bronchiolitis treated in the hospital be-tween April 2015 and May 2017 were divided into control group(n=46)and study group(n=46)by random number table. Control group were treated with saline + salbutamol aerosol inhalation,and study group were treated with hypertonic saline +salbutamol aerosol inhalation.The differences in serum contents of inflammatory mediators and oxidative stress indexes were compared between the two groups at different points in time.Results:There was no statistically significant difference in the se-rum contents of inflammatory mediators and oxidative stress indexes between the two groups at T 0.At T1 and T2,serum in-flammatory mediators IL-4,IL-6,IL-8 and hs-CRP contents of study group were lower than those of control group;serum ox-idative stress indexes AOPPs,LHP and MDA contents were lower than those of control group whereas CAT and SOD contents were higher than those of control group.Conclusion:Hypertonic saline + salbutamol aerosol inhalation can be more effective in inhibiting systemic inflammatory response and oxidative stress response and relieving the illness in children with bronchiolitis.关键词
毛细支气管炎/高渗盐水/沙丁胺醇雾化吸入/炎症反应/应激反应Key words
bronchiolitis/hypertonic saline/salbutamol aerosol inhalation/inflammatory response/stress response分类
医药卫生引用本文复制引用
李小妹,王念平,王勇,殷莉..高渗盐水+沙丁胺醇雾化吸入对毛细支气管炎患儿炎症应激反应的影响[J].海南医学院学报,2018,24(3):327-330,4.基金项目
湖北省科学技术项目项目(EK2016D210019000772)This study was supported by Science and Technology Project of Hubei Province(EK2016D210019000772) （EK2016D210019000772）
