海南医学院学报2018，Vol.24Issue(3)：417-420,4.DOI:10.13210/j.cnki.jhmu.20180124.001
急性脑梗死伴2型糖尿病患者焦虑情绪与神经损伤程度、氧化应激反应的相关性研究
The correlation of anxiety with nerve injury and oxidative stress response in patients with a-cute cerebral infarction complicated by type 2 diabetes mellitus
摘要
Abstract
Objective:To study the correlation of anxiety with nerve injury and oxidative stress response in patients with acute cerebral infarction complicated by type 2 diabetes mellitus.Methods:Patients with acute cerebral infarction complicated by type 2 diabetes mellitus that were treated in Jingzhou First People's Hospital between March 2015 and April 2017 were se-lected and divided into anxiety group and non-anxiety group according to HAMA score;the healthy subjects who received phys-ical examination during the same period were selected as the control group.The serum contents of nerve injury markers,oxida-tive stress indexes and apoptosis indexes of three groups of subjects were measured.Results:Serum NSE,Glu,β-actin, NF155,sTM,MDA,ox-LDL,AOPP,sFas,sFasL and Caspase-3 levels of anxiety group and non-anxiety group were signifi-cantly higher than those of control group whereas GPx,SOD,Bcl-2 and Livin contents were lower than those of control group;serum NSE,Glu,β-actin,NF155,sTM,MDA,ox-LDL,AOPP,sFas,sFasL and Caspase-3 contents of anxiety group were significantly higher than those of non-anxiety group whereas GPx,SOD,Bcl-2 and Livin contents were lower than those of non-anxiety group.Conclusion:The anxiety in patients with acute cerebral infarction complicated by type 2 diabetes mellitus can aggravate the degree of nerve injury and oxidative stress response.关键词
急性脑梗死/2型糖尿病/焦虑/氧化应激/细胞凋亡Key words
acute cerebral infarction/type 2 diabetes mellitus/anxiety/oxidative stress/apoptosis分类
医药卫生引用本文复制引用
朱作权,陈皓..急性脑梗死伴2型糖尿病患者焦虑情绪与神经损伤程度、氧化应激反应的相关性研究[J].海南医学院学报,2018,24(3):417-420,4.基金项目
荆州市科学技术局计划项目(2013-18)This study was supported by the Plan Project of Science and Technology Bureau in Jingzhou City(2013-18). （2013-18）
