海南医学院学报2018，Vol.24Issue(4)：448-451,4.DOI:10.13210/j.cnki.jhmu.20180203.005
硝普钠联合替罗非班冠脉内注射对PCI术中无复流患者心肌损伤程度的影响
Effect of intracoronary sodium nitroprusside and tirofiban injection on myocardial injury in pa-tients with no reflow in PCI
摘要
Abstract
Objective:To study the effect of intracoronary sodium nitroprusside and tirofiban injection on myocardial in-jury in patients with no reflow in PCI.Methods:Patients with acute coronary syndrome who underwent PCI and had no reflow in Gong'an County People's Hospital in Hubei Province between August 2014 and July 2017 were selected as the research sub-jects and randomly divided into two groups,combined group accepted intracoronary sodium nitroprusside and tirofiban injection during PCI,and control group accepted intracoronary tirofiban injection during PCI.The serum levels of myocardial injury in-dexes,oxidative stress indexes and inflammatory mediators of the two groups were measured before treatment and 1 day after treatment.Results:1 day after treatment,serum CK-MB,H-FABP,sFas,cMyBP-C,MPO,MDA,Caspase-3,MCP-1,IL-1β,IL-18,MMP2 and MMP9 levels of both groups were significantly lower than those before treatment whereas SOD and NQO-1 levels were higher than those before treatment,and serum CK-MB,H-FABP,sFas,cMyBP-C,MPO,MDA,Caspase-3,MCP-1,IL-1β,IL-18,MMP2 and MMP9 levels of combined group were significantly lower than those of control group whereas SOD and NQO-1 levels were higher than those control group.Conclusion:Intracoronary sodium nitroprusside and tirofiban injection can reduce the myocardial injury in patients with no reflow in PCI.关键词
经皮冠状动脉介入治疗/硝普钠/替罗非班/无复流/心肌损伤Key words
percutaneous coronary intervention/sodium nitroprusside/tirofiban/no reflow/myocardial injury分类
医药卫生引用本文复制引用
夏向阳..硝普钠联合替罗非班冠脉内注射对PCI术中无复流患者心肌损伤程度的影响[J].海南医学院学报,2018,24(4):448-451,4.基金项目
荆州市科技发展计划项目(20131309) This study was supported by Jingzhou Municipal Science and Technology Development Project(Grant No.20131309). （20131309）
