海南医学院学报2018，Vol.24Issue(4)：492-495,499,5.DOI:10.13210/j.cnki.jhmu.20180129.011
DPP-4抑制剂联合二甲双胍对2型糖尿病患者血糖控制、氧化应激及炎症反应的影响
Effects of DPP-4 inhibitor combined with metformin on blood glucose control,oxidative stress and inflammatory response in patients with type 2 diabetes mellitus
摘要
Abstract
Objective:To investigate the effects of DPP-4 inhibitor combined with metformin on blood glucose control, oxidative stress and inflammatory response in patients with type 2 diabetes mellitus(T2DM).Methods:138 patients with new-ly diagnosed T2DM who were treated in the hospital between March 2016 and April 2017 were divided into routine group(n=69)and combined treatment group(n=69)by random number table method.Routine group were treated with metformin alone and combined treatment group received DPP-4 inhibitor combined with metformin therapy.The differences in blood glucose control as well as oxidative stress-related indicator and inflammatory factor contents were compared between the two groups be-fore and after treatment.Results:Before treatment,the differences in blood glucose index levels in peripheral blood as well as the oxidative stress index and inflammatory mediator contents in serum were not statistically significant between the two groups.After 4 weeks of treatment,blood glucose indexes FBG and HOMA-IR levels in peripheral blood of combined treat-ment group were lower than those of routine group;oxidative stress indexes MDA and LHP contents in serum were lower than those of routine group whereas GSH-Px and T-AOC contents were higher than those of routine group;inflammatory mediators hs-CRP,IL-1 and IL-6 contents in serum were lower than those of routine group.Conclusion:DPP-4 inhibitor combined with metformin therapy can effectively control the blood glucose and suppress the systemic oxidative stress and inflammatory re-sponse in T2DM patients.关键词
2型糖尿病/DPP-4抑制剂/血糖控制/氧化应激/炎症反应Key words
type 2 diabetes mellitus/DPP-4 inhibitor/blood glucose control/oxidative stress/inflammatory response分类
医药卫生引用本文复制引用
王科峰,柴林燕,张允东,高海燕..DPP-4抑制剂联合二甲双胍对2型糖尿病患者血糖控制、氧化应激及炎症反应的影响[J].海南医学院学报,2018,24(4):492-495,499,5.基金项目
陕西省教育厅专项科研项目(2013JK0776) This study was supported by Special Scientific Research Project of Education Department of Shaanxi Province(Grant No.2013JK0776). （2013JK0776）
