海南医学院学报2018，Vol.24Issue(4)：504-507,511,5.DOI:10.13210/j.cnki.jhmu.20180208.002
膳食纤维肠内营养对结直肠癌术后炎症反应、抗肿瘤免疫应答的影响
Effect of dietary fiber enteral nutrition on inflammatory response and anti-tumor immune re-sponse after colorectal cancer surgery
摘要
Abstract
Objective:To study the effect of dietary fiber enteral nutrition on inflammatory response and anti-tumor im-mune response after colorectal cancer surgery.Methods:162 patients who underwent radical operation for colorectal cancer in West China Hospital,Sichuan University between March 2015 and August 2017 were selected as the research subjects and ran-domly divided into the dietary fiber group who accepted dietary fiber enteral nutrition intervention and the control group who accepted conventional nutrition intervention.The number of intestinal flora was determined before surgery and at the first defe-cation after surgery;the inflammatory response indexes and immune response indexes were measured before surgery as well as 3 days and 5 days after surgery.Results:At the first defecation after surgery,the bifidobacteria,lactobacillus,Escherichia coli and enterococcus contents in the feces of both groups were lower than those before surgery,and the bifidobacterium and lacto-bacillus contents in feces of dietary fiber group were higher than those of control group whereas Escherichia coli and enterococ-cus contents were lower than those of control group;3 days and 5 days after surgery,NF-κB,IL-1,TNF-α and IL-8 contents in serum as well as Treg,Th17,Th22,TGF-β,IL-17 and IL-22 contents in peripheral blood of both groups of patients were significantly higher than those before surgery,and NF-κB,IL-1,TNF-α and IL-8 contents in serum as well as Treg,Th17, Th22,TGF-β,IL-17 and IL-22 contents in peripheral blood of dietary fiber group were lower than those of control group.Con-clusion:The dietary fiber enteral nutrition intervention after colorectal cancer surgery can inhibit the inflammatory response and improve the anti-tumor immune response.关键词
结直肠癌/膳食纤维/炎症反应/免疫应答Key words
colorectal cancer/dietary fiber/inflammatory response/immune response分类
医药卫生引用本文复制引用
杜晓娅..膳食纤维肠内营养对结直肠癌术后炎症反应、抗肿瘤免疫应答的影响[J].海南医学院学报,2018,24(4):504-507,511,5.基金项目
国家自然科学基金(NSFC 81062341) This study was supported by the National Natural Science Foundation of China(NSFC 81062341). （NSFC 81062341）
