海南医学院学报2018，Vol.24Issue(4)：512-514,518,4.DOI:10.13210/j.cnki.jhmu.20180129.009
急性髓系白血病患者血清中sPD-L1、VEGF的表达及意义
Expression levels and significance of sPD -L1 and VEGF in serum of patients with acute my-eloid leukemia
摘要
Abstract
Objective:To investigate the expression level and correlation of soluble programmed death factor(sPD-L1) and vascular endothelial grow th factor(VEGF)in serum of patients with acute myeloid leukemia.Methods:From January 2016 to October 2017 in the first affiliated hospital of Jiamusi university of 36 cases of incipient did not treat patients with acute mye-loid leukemia as at the beginning of AML group,after 1-2 standard chemotherapy,27 cases with complete remission as com-plete remission group,9 cases did not ease as a group.In the same period,20 healthy patients were selected as the healthy con-trol group.The expression levels of sPD-L1 and VEGF were detected by enzyme-linked immunoassay(ELISA).Results:The expression of sPD-L1 and VEGF in serum of the initial and unrelieved AML patients was significantly higher than that in the healthy control group,and the difference was statistically significant(P<0.05).After 1-2 standard chemotherapy,the expres-sion of sPD-L1 and VEGF in the serum of patients with complete remission was significantly lower than that in the initial treat-ment group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the total relief group and the control group(P>0.05).There is a significant positive correlation between the two expressions. Conclusion:The high expression of sPD-L1and VEGF in serum may be related to the occurrence,development and prognosis of AML.Therefore,the joint detection of sPD-L1 and VEGF is of some significance to the early diagnosis,monitoring efficacy and prognosis of AML patients.关键词
急性髓细胞白血病/可溶性程序性死亡因子配体-1(sPD-L1)/血管内皮生长因子(VEGF)/免疫酶联Key words
AML/sPD-L1/VEGF/Enzyme-linked immunosorbent assay分类
医药卫生引用本文复制引用
张纯,董航,赵悦荣,李萌..急性髓系白血病患者血清中sPD-L1、VEGF的表达及意义[J].海南医学院学报,2018,24(4):512-514,518,4.基金项目
黑龙江省卫生计生委科研课题(2017-378) This study was supported by Research Project of Heilongjiang Provincial Health and Family Planning Commission(Grant No.2017－378). （2017-378）
