海南医学院学报2018，Vol.24Issue(4)：530-533,4.DOI:10.13210/j.cnki.jhmu.20180129.005
肺炎合并脓毒症患儿外周血调节性T细胞含量与炎症应激反应、免疫应答的相关性研究
The correlation of peripheral blood regulatory T cell content with inflammatory stress re-sponse and immune response in children with both pneumonia and sepsis
摘要
Abstract
Objective:To investigate the correlation of peripheral blood regulatory T cell content with inflammatory stress response and immune response in children with both pneumonia and sepsis.Methods:90 children with both pneumonia and sepsis who were treated in our hospital between September 2014 and April 2017 were selected as sepsis group and 100 healthy children who received vaccination in our hospital during the same period were selected as normal control group.The differences in peripheral blood regulatory T cell(Treg)expression as well as serum inflammatory mediator,oxidative stress in-dex and immunoglobulin contents were compared between the two groups of children.Pearson test was used to evaluate the correlation between Treg expression and disease in patients with both pneumonia and sepsis.Results:Peripheral blood Treg ex-pression of sepsis group was significantly higher than that of control group;serum inflammatory mediators PCT,hs-CRP, TNF-α and IL-6 contents were higher than those of control group;serum oxidative stress indexes NO and MDA contents were higher than those of control group whereas SOD content was lower than that of control group;immunoglobulin IgA,IgM and IgG contents were lower than those of normal control group.Pearson test showed that peripheral blood Treg expression of chil-dren with both pneumonia and sepsis was directly correlated with the inflammatory stress response and immune response.Con-clusion:Peripheral blood Treg expression significantly increases in children with both pneumonia and sepsis,which could di-rectly affect the inflammatory stress response extent and humoral immune function.关键词
脓毒症/肺炎/调节性T细胞/炎症反应/氧化应激/免疫球蛋白Key words
sepsis/pneumonia/regulatory T cell/inflammatory response/oxidative stress/immunoglobulin分类
医药卫生引用本文复制引用
何源,易海英,杨树杰,黄杰,魏贤..肺炎合并脓毒症患儿外周血调节性T细胞含量与炎症应激反应、免疫应答的相关性研究[J].海南医学院学报,2018,24(4):530-533,4.基金项目
湖北省医学科技计划项目(WJ2015Z124) This study was supported by Hubei Provincial Medical Science and Technology Project(Grant No.WJ2015Z124). （WJ2015Z124）
