海南医学院学报2018，Vol.24Issue(4)：548-551,4.DOI:10.13210/j.cnki.jhmu.20180129.010
妊娠期高血压疾病患者左心功能超声评估及与血清细胞因子含量的相关性
The ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents
摘要
Abstract
Objective:To investigate the ultrasound assessment of left cardiac function in patients with gestational hy-pertension and its correlation with serum cytokine contents.Methods:76 patients with gestational hypertension who were trea-ted in Guangyuan Central Hospital between August 2015 and February 2017 were selected as gestational hypertension group, and 50 healthy pregnant women who received regular prenatal examination in Guangyuan Central Hospital during the same pe-riod were selected as normal control group.The differences in the ultrasonic left cardiac function parameter levels as well as ser-um contents of endothelial injury indexes and inflammatory factors were compared between the two groups of pregnant women. Pearson test was used to assess the correlation of ultrasonic left cardiac function parameter levels of gestational hypertension with serum endothelial injury index and inflammatory factor contents.Results:LAVmax,LVESV and LVEDV levels in gesta-tional hypertension group were significantly higher than those in normal control group;serum endothelial injury indexes NO and PGE2 contents were lower than those of normal control group whereas ET-1 content was higher than that of normal control group;serum inflammatory factors IL-2,IFN-γ,IL-10,IL-13,IL-17 and IL-23 contents were significantly higher than those of normal control group.Correlation analysis showed that the ultrasonic left cardiac function parameter levels in patients with gestational hypertension were directly correlated with serum content of endothelial injury indexes and inflammatory factors. Conclusion:Ultrasonic left cardiac function parameter levels significantly change in patients with gestational hypertension,and the specific levels are directly correlated with the degree of endothelial injury and inflammatory response in the pregnant women.关键词
妊娠期高血压疾病/超声左心功能/内皮功能/炎症因子Key words
gestational hypertension/ultrasonic left cardiac function/endothelial function/inflammatory factor分类
医药卫生引用本文复制引用
胡辉明,宋小伟,周薪雨..妊娠期高血压疾病患者左心功能超声评估及与血清细胞因子含量的相关性[J].海南医学院学报,2018,24(4):548-551,4.基金项目
四川省卫生厅科技项目资助(15A0021) This study was supported by Science and Technology Project of Sichuan Health Department(Grant No.15A0021). （15A0021）
