海南医学院学报2018，Vol.24Issue(4)：556-559,4.DOI:10.13210/j.cnki.jhmu.20180129.004
大剂量VitC联合免疫球蛋白治疗小儿病毒性心肌炎的临床价值
Clinical value of high-dose VitC + immunoglobulin for the treatment of viral myocarditis in children
摘要
Abstract
Objective:To study the clinical value of high-dose VitC + immunoglobulin for the treatment of viral myo-carditis in children.Methods:Children who were diagnosed with viral myocarditis in the hospital between May 2014 and March 2017 were selected as the research subjects and divided into two groups by random number table,observation group received high-dose VitC + immunoglobulin combined with conventional symptomatic and supportive treatment and control group re-ceived conventional symptomatic and supportive treatment.The serum levels of myocardial injury indexes,myocardial remode-ling indexes and inflammatory response indexes were measured before treatment as well as at 1 week and 2 weeks after treat-ment.Results:1 week and 2 weeks after treatment,serum CK-MB,cTnI,MDA,BNP,PINP,ICTP,MMP2,MMP9, TGFβ1,TNF-α,ICAM-1,MIP-1α and IL-17 levels of both groups of patients were significantly lower than those before treat-ment,and serum CK-MB,cTnI,MDA,BNP,PINP,ICTP,MMP2,MMP9,TGFβ1,TNF-α,ICAM-1,MIP-1α and IL-17 levels of observation group were lower than those of control group.Conclusion:High-dose VitC + immunoglobulin can reduce the myocardial damage and inhibit the myocardial remodeling and inflammatory response in children with viral myocarditis.关键词
病毒性心肌炎/维生素C/免疫球蛋白/心肌重塑/炎症反应Key words
viral myocarditis/vitamin C/immunoglobulin/myocardial remodeling/inflammatory response分类
医药卫生引用本文复制引用
高瑞波,江红..大剂量VitC联合免疫球蛋白治疗小儿病毒性心肌炎的临床价值[J].海南医学院学报,2018,24(4):556-559,4.基金项目
湖北省卫生和计划生育委员会科研项目(WJ2014MB102) This study was supported by Research Project of Hubei Provincial Health and Family Planning Commission (Grant No.WJ2014MB102) （WJ2014MB102）
