海南医学院学报2018，Vol.24Issue(4)：567-570,4.DOI:10.13210/j.cnki.jhmu.20180207.006
诱导前应用右美托咪定对TURP术中炎症、应激反应及术后疼痛介质分泌的影响
Effect of dexmedetomidine before induction on the inflammatory and stress response in TURP and the secretion of pain mediators after it
摘要
Abstract
Objective:To study the effect of dexmedetomidine before induction on the inflammatory and stress response in transurethral resection of prostate(TURP)and the secretion of pain mediators after it.Methods:Patients with benign pros-tatic hyperplasia who underwent TURP in Mianyang Central Hospital between June 2014 and March 2017 were selected as the research subjects and randomly divided into the Dex group who accepted dexmedetomidine combined with intraspinal anesthesia and the control group who accepted intraspinal anesthesia.The contents of inflammatory response indexes,stress response in-dexes and pain mediators in serum of the two groups were measured before surgery as well as 1 day and 3 days after surgery. Results:Serum NF-κB,TNF-α,IL-8,HMGB1,VCAM1,Cor,ACTH,AT-II,ALD and CRP levels of both groups of pa-tients during surgery were higher than those before surgery,and serum CGRP,BK,SP and PGE2 levels 1 day and 3 days after surgery were higher than those before surgery(P<0.05);serum NF-κB,TNF-α,IL-8,HMGB1,VCAM1,Cor,ACTH, AT-II,ALD and CRP levels of Dex group of patients during surgery were lower than those of control group,and serum CGRP,BK,SP and PGE2 levels 1 day and 3 days after surgery were lower than those of control group(P<0.05).Conclusion:The application of dexmedetomidine before induction has inhibitory effect on the activation of inflammatory and stress response in TURP and the secretion of pain mediators after TURP.关键词
良性前列腺增生症/经尿道前列腺切除术/炎症反应/应激反应/疼痛介质Key words
benign prostatic hyperplasia/transurethral resection of prostate/inflammatory response/stress response/pain mediator分类
医药卫生引用本文复制引用
杨静,夏氢..诱导前应用右美托咪定对TURP术中炎症、应激反应及术后疼痛介质分泌的影响[J].海南医学院学报,2018,24(4):567-570,4.基金项目
绵阳市卫生局科研项目(201319) This study was supported by the Scientific Research Project of Mianyang Municipal Bureau of Health(201319). （201319）
