湖南中医药大学学报2018，Vol.38Issue(2)：130-135,6.DOI:10.3969/j.issn.1674-070X.2018.02.004
心血瘀阻证动态演变过程生物信息学研究
Research on Dynamic Evolution of Heart Blood Stasis Syndrome Based on Bioinformatics
摘要
Abstract
Objective To investigate the three stages of metabolic pathways on early-stage of blood stasis syndrome, sub-stage of blood stasis syndrome and stage of heart blood stasis syndrome during the dynamic evolution of heart blood stasis syndrome in patients with coronary heart disease. Methods Signal pathways were analyzed by using KEGG. Molecular annotations of metabolites, related enzymes or transporters and their associated properties were analyzed by using HMDB. Metabolic pathways visualization were analyzed by using metPA network software. Results Metabolic pathways showed that 12 metabolites were involved in 22 metabolic pathways. The influence value of 6 pathways (biosynthesis of aminoacyl-tRNA, biosynthesis of valine, leucine and isoleucine, degradation of valine, leucine and isoleucine, metabolism of arginine and proline, metabolism of galactose, metabolism of D-Arginine and D-ornithine) was P<0.05. Conclusion The six closely related pathways are mainly concentrated in sub-stage of blood stasis syndrome and stage of heart blood stasis syndrome.关键词
心血瘀阻证/演变过程/代谢组学Key words
heart blood stasis syndrome/dynamic evolution/metabonomics分类
医药卫生引用本文复制引用
刘培,肖隋熙,罗颖,胡伟,简维雄,李杰..心血瘀阻证动态演变过程生物信息学研究[J].湖南中医药大学学报,2018,38(2):130-135,6.基金项目
国家自然科学基金项目(81202647,81774207,81673963) （81202647,81774207,81673963）
国家重点学科项目(2014-16) （2014-16）
湖南省中医药科研计划项目(201427) （201427）
中国博士后基金资助(2013M530355). （2013M530355）
