湖南中医药大学学报2018，Vol.38Issue(2)：136-140,5.DOI:10.3969/j.issn.1674-070X.2018.02.005
丹参通络解毒汤对冠心病不稳定型心绞痛患者黏附分子的影响
Effects of Danshen Tongluo Jiedu Decoction on Adhesion Molecules in Patients with Unstable Coronary Artery Disease
摘要
Abstract
Objective To observe the effects of Danshen Tongluo Jiedu decoction on blood lipids, serum intercellular adhesion molecule-1 (ICAM 1) and vascular cell adhesion molecule 1 (VCAM 1) in unstanble angina patients with stagnant heat and toxin and toxin damaging heat-nutrient syndromes. Methods Sixty unstanble angina patients with stagnant heat and toxin and toxin damaging heat-nutrient syndromes were selected. The 60 patients were randomly divided into two groups, 30 cases in each group. The control group was treated with conventional medicine, and the observation group was treated with Danshen Tongluo Jiedu decoction on the basis of control group. The changes of TCM syndrome scores, electrocardiogram, angina, and the levels of TC, TG, HDL-C, LDL-C, ICAM-1 and VCAM-1 were observed after treatment for two months. Results The effects of TCM syndrome scores, electrocardiogram, angina in observation group were higher than that of the control group, and the difference was statistically significant (P<0.05). The levels of TC, TG, LDL-C, ICAM-1 and VCAM-1 after treatment were lower than that before treatment, the level of HDL-C increased, and the improvment of blood lipid and adhere factor levels was better than that of the control group, the differences were statistically significant (P<0.05). Conclusion The effects of Danshen Tongluo Jiedu decoction in treating unstanble angina patients with stagnant heat and toxin and toxin damaging heat-nutrient syndromes were obvious, and its mechanism may be related to the regulation of blood lipid metabolism, reducing ICAM-1 and VCAM-1 levels.关键词
丹参通络解毒汤/冠心病不稳定型心绞痛/血清细胞间黏附分子-1/血管细胞黏附分子-1/血脂Key words
Danshen Tongluo Jiedu decoction/unstable coronary artery disease/ICAM-1/VCAM-1/blood lipid分类
医药卫生引用本文复制引用
李鑫辉,王静雯,肖青,杜建芳,吴若霞,李彩云,徐玛丽,张睿尧..丹参通络解毒汤对冠心病不稳定型心绞痛患者黏附分子的影响[J].湖南中医药大学学报,2018,38(2):136-140,5.基金项目
国家自然科学基金面上项目(30973750) （30973750）
湖南省教育厅科学研究研重点项目(15A143) （15A143）
湖南省中医药科研计划项目(201559) （201559）
长沙市科技计划项目(kq1706058) （kq1706058）
研究生创新课题(2016cx21). （2016cx21）
