湖南中医药大学学报2018，Vol.38Issue(2)：141-144,4.DOI:10.3969/j.issn.1674-070X.2018.02.006
滋肾活血方对血管性痴呆大鼠NR2A表达的影响
Effect of Zishen Huoxue Decoction on Expression of NR2A in Rats with Vascular Dementia
摘要
Abstract
Objective To investigate the effect of Zishen Huoxue decoction on the expressiom of NR2A in rats with vascular dementia (VD). Methods This VD model rats were built by the improved 2-VO. The rats were randomly divide into the sham-operation group, the model group, the Zishen Huoxue group and the oxiracetam group. After giving medicine for 4 weeks later, the expression of NR2A and its mRNA were measured by immunohistochemical analysis and RT-PCR. Results Compared with the model group, the expression of NR2A and its mRNA in Zishen Huoxu decoction group and oxiracetam group increased (P<0.05). Conclusion Zishen Huoxue decoction could improve the ability of learning and memory, which might be associated with the up-regulation of the expression of NR2A.关键词
滋肾活血方/血管性痴呆/N-甲基-D-天门冬氨酸Key words
Zishen Huoxue decoction/vascular dementia/N-methyl-D-aspartate分类
医药卫生引用本文复制引用
任晨斌,伍大华,郭晨,谢乐..滋肾活血方对血管性痴呆大鼠NR2A表达的影响[J].湖南中医药大学学报,2018,38(2):141-144,4.基金项目
湖南省中医药管理局重点项目(201528). （201528）
