化学工程2017，Vol.45Issue(11)：1-6,22,7.DOI:10.3969/j.issn.1005-9954.2017.11.001
粒径相关的海藻酸盐/壳聚糖微球膜性能
Properties of alginate/chitosan microsphere membranes associated with gel bead diameter
摘要
Abstract
Diameter is an important parameter of microspheres.In this study,with calcium alginate (Ca-Alg) gel beads having different diameters (202 μm,413 μm and 809 μm) and vitamin B12(VB12),bovine serum albumin (BSA),chitosan (CS) as model molecules,the effect of the gel bead diameter on the formation and performance of calcium alginate/chitosan (Ca-Alg/CS)microspheres was investigated.The structure and morphology were characterized by scanning electron microscopy (SEM),fourier transform infrared spectroscopy (FTIR) and laser confocal microscopy (CLSM).The stability of (Ca-Alg/CS) microspheres membrane was characterized by swelling ratio.The results showed that the gel structure,diffusion property and formation of the polyelectrolyte membrane of Ca-Alg/CS microspheres are correlated with the diameter of Ca-Alg gel beads.With the decrease of the diameter of gel beads,the gel structure tended to be denser and the resistance to molecular diffusion increased.During the membrane forming reaction,gel beads with smaller diameter provided more cross-linking sites for membrane formation reaction,forming a thicker and denser layer of polyelectrolyte membrane with continuous structure on the surface of gel beads.With excellent membrane strength and swelling stability,Ca-Alg/CS microspheres have significant advantages applied in the field of cell immobilization.关键词
海藻酸钙/壳聚糖/粒径/扩散/聚电解质复合膜Key words
calcium alginate/chitosan/diameter/diffusion/polyelectrolyte membrane分类
化学化工引用本文复制引用
高婷,温惠云,潘士印,黄赛朋,许宁侠,徐佳桐,刘先宁,贾朝,薛伟明..粒径相关的海藻酸盐/壳聚糖微球膜性能[J].化学工程,2017,45(11):1-6,22,7.基金项目
陕西省自然科学基金资助项目(2015JM2044 （）
2014JQ2067) （）
国家自然科学基金资助项目(21306152) （21306152）
陕西省教育厅专项科研计划项目(16JK1770) （16JK1770）
