摘要
Abstract
Objective To evaluate the effect of pioglitazone on fasting blood glucose (FBG),postprandial 2 h blood sugar (2 hPG) and glycated hemoglobintype (HbA1c) in patients with type 2 diabetes mellitus.Methods Totally 90 patients with type 2 diabetes mellitus were divided into observation group and control group,45 cases in each group.The observation group was treated with conventional therapy for diabetes and pioglitazone,while the control group was treated with conventional therapy for diabetes.The clinical efficacy of FBG and 2 hPG were compared between two groups,The incidence rate of adverse reactions was compared.The changes of FBG,2 hPG,HbA1c,adiponectin and serum inflammatory factors before and after treatment were compared between two groups.Results The effective rates of FBG and 2 hPG in observation group were significantly higher than the control group (P ＜ 0.05).There was no significant difference in the number of patients with adverse reactions between two groups (P ＞ 0.05).After treatment,levels of FBG,2 hPG,HbA1 c were significantly lower than those before treatment,and decreasing degrees of FBG,2 hPG and HbA1c in the observation group were significantly greater than the control group (P ＜ 0.05).After treatment,adiponectin level significantly increased in both groups,and serum inflammatory factors such as TNF-α and IL-6 were significantly lower than those before treatment,and the increasing degree of adiponectin and decreasing degrees of inflammatory factors in the observation group were significantly greater than the control group (P ＜ 0.05).Conclusion Pioglitazone is effective in the treatment of patients with type 2 diabetes.It can reduce the serum inflammatory factors and FBG,2 hPG,and HbA1c.关键词
吡格列酮/2型糖尿病/空腹血糖/餐后2h血糖/糖化血红蛋白Key words
pioglitazone/type 2 diabetes mellitus/fasting blood glucose/postprandial 2 h blood sugar/glycated hemoglobintype分类
医药卫生
