解放军医学院学报2017，Vol.38Issue(11)：999-1003,5.DOI:10.3969/j.issn.2095-5227.2017.11.001
不同血压分级的2型糖尿病患者血清神经肽Y和左心结构、功能的差异及意义
Serum NPY and its correlation with left heart morphology and function in type 2 diabetes patients at different blood pressure levels
摘要
Abstract
Objective To study the changes of serum neuropeptide Y (NPY) and its correlation with left heart morphology and function in patients with type 2 diabetes at different blood pressure levels.Methods One hundred and sixty five type 2 diabetes patients,including 40 type 2 diabetes patients (DM group) and 125 type 2 diabetes patients with hypertension (DH1 group,n=40;DH2 group,n=41;DH3 group,n=44),35 healthy people as NS group were enrolled in this study.The serum NPY level was detected by ELISA.Echocardiographic parameters including interventricular septal thickness (IVST),left ventricular end-diastolic diameter (LVEDD),left ventricular posterior wall thickness (LVPWT),left atrial diameter (LAD),and left ventricular ejection fraction (LVEF) were measured,then left ventricular mass index (LVMI) and E/A were calculated.The differences in all the indicators were compared between each group.Results There were significant differences in echocardiographic parameters between NS group and diabetes groups (DM group,DH1group,DH2 group and DH3 group) (all P ＜ 0.05).With increasing of hypertension grade,the levels of IVST,LVEDD,LVPWT,LAD,1LVMI and NPY in DM,DH1,DH2 and DH3 groups increased,and LVEF,E/ A decreased gradually.However,among DH groups,only the differences between DH3 group and other 2 groups were significant.Echocardiographic parameters in DH3 group,DH2 group and DH1 group were as follows,IVST (11.71 ± 0.82 mm vs 10.66 ± 1.06 mm,9.89 ± 0.93 mm);LVEDD (49.36 ± 2.14 mm vs 44.67 ± 2.99 mm,41.86 ± 2.89 mm);LVPWT (10.02 ± 0.85 mm vs 8.86 ± 0.85 mm,6.9 ± 0.92 mm);LVMI (136.96 ± 11.17 g/m2 vs 70.68 ± 14.35 g/m2,64.10 ± 8.46 g/m2);NPY:(15.53 ± 4.35ng/L vs 10.56 ± 3.64 ng/L,8.67 ± 3.52 ng/L),LVEF (60.97％ ± 6.70％ vs 67.62％ ± 3.24％,70.71％ ± 5.17％) and E/A (0.50 ± 0.09 vs 1.07 ± 0.32,1.33 ± 0.45) (all P ＜ 0.05).LAD in DH2 group and DH3 group were 31.06 ± 2.55 mm and 29.91 ± 1.82 mm,which were significantly lower than that in DH1 group (36.10 ± 3.02 mm) (P ＜ 0.05).Further multiple regression analysis showed that LVMI was independently correlated with the level of NPY (r=0.57,P=0.000).Conclusion With the rising of blood pressure,the left ventricular systolic function decreases,while left ventricular hypertrophy progresses,so does the levels of serum NPY.NPY may play an important role in the changes of left heart morphology and function in diabetes patients with hypertension.关键词
2型糖尿病/高血压/神经肽Y/左心功能Key words
type 2 diabetes mellitus/hypertension/neuropetide Y/left ventricular function分类
医药卫生引用本文复制引用
李宝新,郭淑芹,张鑫,常文龙,李立琴,王翯,马爽,张云良..不同血压分级的2型糖尿病患者血清神经肽Y和左心结构、功能的差异及意义[J].解放军医学院学报,2017,38(11):999-1003,5.基金项目
国家自然科学基金青年基金项目(81500644) （81500644）
河北省医学科学研究课题计划(20160282) （20160282）
保定市科学技术研究与发展计划(16ZF071)Supported by the National Natural Science Foundation of China (81500644) （16ZF071）
Hebei Medical Science Research Project (20160282) （20160282）
Baoding Science and Technology Research and Development Project (16ZF071) （16ZF071）
