解放军医学院学报2017，Vol.38Issue(11)：1033-1036,1039,5.DOI:10.3969/j.issn.2095-5227.2017.11.009
107例韧带样纤维瘤病临床病理学特征及预后分析
Clinicopathologic features and prognostic factors of desmoid-type fibromatosis: An analysis of 107 cases
王晓聪 1宋欣 1刘晋红 1孙海波 1李金龙 1石怀银1
作者信息
摘要
Abstract
Objective To study the clinicopathological features and risk factors for the recurrence of desmoid-type fibromatosis (aggressive fibromatosis).Methods Clinical data about 107 desmoid-type fibromatosis patients who admitted to Chinese PLA General Hospital from 2005 to 2015 were collected.The clinicopathological features and the expressions of P53 and β-catenin were used to analyze the factors influencing the prognosis of desmoid-type fibromatosis retrospectively.Results Of the 107 cases,49 males (45.8％) and 58 females (54.2％) were included with mean age of 27.6 years (ranging from 1 to 78 years).The tumors located at upper extremity in 8 cases,lower extremity in 26 cases,trunk in 62 cases,head and neck in 11 cases.The mean diameter of the tumors was 8.9 cm (ranging from 1.2 to 30.0 cm).The median follow-up time was 6.4 years (ranging from 3.1 to 11.0 years).Of the 107 cases,51 (47.7％) patients recurred after surgical resection.The recurrence develped in 2 to 70 months with median of 12 months.Univariate analysis revealed that surgical margin (P=0.000),tumor location (P=0.001),nuclear β-catenin (P=0.026) and P53 (P=0.001) expression were the factors influencing tumor recurrence.Multivariate analysis revealed that surgical margin (P=0.000),tumor location (P=0.003) and P53 expression (P=0.000) were independent prognostic factors.Conclusion Positive surgical margin is a risk factor for the recurrence of desmoid-type fibromatosis.The expression of P53 is a poor prognostic factor,suggesting further treatment after surgery.关键词
韧带样纤维瘤病/复发/免疫组化/β连接蛋白/P53蛋白Key words
desmoid-type fibromatosis/relapse/immunohistochemistry/β-catenin/P53 protein分类
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王晓聪,宋欣,刘晋红,孙海波,李金龙,石怀银..107例韧带样纤维瘤病临床病理学特征及预后分析[J].解放军医学院学报,2017,38(11):1033-1036,1039,5.
