临床口腔医学杂志2018，Vol.34Issue(2)：74-76,3.DOI:10.3969/j.issn.1003-1634.2018.02.004
种植体周围炎性组织中RANKL及OPG表达水平的研究
Study on RANKL and OPG mRNA expression levels in inflamed tissue of patients with peri-implantitis
摘要
Abstract
Objective:To observed the expression levels of RANKL and OPG mRNA in inflamed tissue of patients with peri-implantitis.Methods:Inflamed tissue were collected from the inflamed implants of patients with peri-implantitis(n=8).Healthy gingival tissue were collected from healthy control group(n=8).The mRNA expression levels for RANKL and OPG were evaluated by real-time quantitative polymerase chain reaction.The relationship of RANKL and probing depth(PD) was explored by Spearman analysis.Results:The data demonstrated the expression of RANKL and OPG were detected in both groups.The level of RANKL was(15.77 ± 12.92)-fold significantly higher in peri-implantitis group than in healthy control (P<0.05)and the comparison of OPG level was not statistically significant(P >0.05).Spearman analysis revealed that there was a negative correlation between RANKL level and PD.Conclusion:The raised RANKL/OPG ratio might play an im-portant role in the bone loss in peri-implantitis.关键词
种植体周围炎/RANKL/OPG/实时荧光定量PCRKey words
Peri-implantitis/RANKL/OPG/Real-time quantitative PCR分类
医药卫生引用本文复制引用
刘于冬,黄宝鑫,李志鹏,陈卓凡..种植体周围炎性组织中RANKL及OPG表达水平的研究[J].临床口腔医学杂志,2018,34(2):74-76,3.基金项目
国家自然科学基金(81400550,81470783) （81400550,81470783）
广东省自然科学基金(2015A030311051,2016A030310173) （2015A030311051,2016A030310173）
广东省医学科研基金(B2014166) （B2014166）
