临床与实验病理学杂志2017，Vol.33Issue(11)：1234-1237,4.DOI:10.13315/j.cnki.cjcep.2017.11.012
食管鳞状细胞癌中GFRα3蛋白的表达及临床意义
Expression and clinical significance of GFRα3 in esophagus squamous cell carcinoma
陈雅琪 1蹇顺海 1黄一凡 1文彬1
作者信息
- 1. 川北医学院病理教研室/附属医院病理科,南充637000
- 折叠
摘要
Abstract
Purpose To investgate the expression and clinical significance of GFRα3 in esophagus squamous cell carcinoma (ESCC).Methods Expression of GFRα3 in 114 esophagus squamous cell carcinoma,17 cases of high grade intraepithelial neoplasia and Tis,25 cases nomal tissue was detected by immunohistochemistry.Expression of GFRα3 in 12 paired flesh tissues had also been determined by Western-blot.Results The positive expression of GFRα3 in nomal esophageal tissues,high grade intraepithelial tissues and Tis was 0,29.4％,76.3％ respectively by immunohistochemistry.Expression of GFRα3 in carcinomatous tissues was higher than that of adjacent tissues (P ＜ 0.05).Moreover,the expression of GFRα3 was significantly associated with depth of invasion,higher clinical stage and survival outcome of patients with ESCC.Conclusion The expression of GFRα3 maybe a useful predictor of disease depth of invasion,progression and outcome in ESCC.关键词
食管肿瘤/鳞状细胞癌/GFRα3/免疫组织化学/Western blotKey words
esophagus neoplasm/squamous cell carcinoma/GFRα3/immunohistochemistry/Western blot分类
医药卫生引用本文复制引用
陈雅琪,蹇顺海,黄一凡,文彬..食管鳞状细胞癌中GFRα3蛋白的表达及临床意义[J].临床与实验病理学杂志,2017,33(11):1234-1237,4.
