老年医学与保健2017，Vol.23Issue(5)：389-391,395,4.
针刺对老年膝骨关节炎患者炎症因子表达的影响
Effect of Acupuncture on Inflammatory Factor Expression in the Elderly with KOA
摘要
Abstract
Objective To explore the effect of acupuncture on the elderly with knee osteoarthritis (KOA).Methods 130 elderly with KOA were selected and randomly divided into 2 groups:observation group (n =67) and control group (n =63);acupuncture at the acupoints of Xue-hai,inner Xi-yan,outer Xi-yan and Yangling-quan plus low frequency pulse with dilatational wave for 20 minutes was performed on the elderly in observation group,once every other day;oral administration of glucosamine hydrochloride was made to the elderly in control group,480 mg once,3 times a day;the courses for both groups lasted for 4 weeks;WOMAC and visual analogue scale (VAS) were applied to the elderly in both groups before and after treatment and the curative effect was assessed with the scores;the expression levels of IL-1β (interleukin-1 beta),IL-6 (interleukin-6),TNF-α (tumor necrosis factor-alpha),PGE2 (prostaglandinsE2) and MMP-13 (matrix metalloproteinase 13) in knee joint fluid were detected.Results After treatment,the score of WOMAC in observation group (48.25 ± 10.52) was lower than that in control group (33.36±6.26),as well as the score of VAS [(2.86 ± 1.10) vs (5.23 ± 1.66) (P＜ 0.05);the contents of IL-1β,IL-6,TNF-α,PGE2 and MMP13 in observation group were all lower than those in control group:[42.59±6.72) pg/mL vs (89.68±12.86) pg/mL,P＜0.05],[(126.38 ±37.25)pg/mL vs (199.26±35.58)pg/mL,P＜0.05],[(6.50±1.02) pg/mLvs (14.22±3.00) pg/mL,P＜0.05],[(102.50±25.58) pg/mL vs (306.69±49.5) pg/mL,P＜0.05] and [(324.65±45.20) pg/mL vs (462.79±56.68)pg/mL,P＜ 0.05].Conclusion Acupuncture can improve the related inflammatory symptoms of the elderly with KOA and reduce the contents of inflammatory factors,it is worthy of wide clinical application.关键词
针刺/骨关节炎,膝/白细胞介素-6/肿瘤坏死因子-α/基质金属蛋白酶13Key words
acupuncture/osteoarthritis, knee/IL-6 (interleukin-6)/TNF-α (tumor necrosis factor-alpha)/MMP-13 (matrix metalloproteinase 13)引用本文复制引用
徐小丽,卢新刚,张霆,高翔,王文昊,苟海昕,朱斌,吴弢..针刺对老年膝骨关节炎患者炎症因子表达的影响[J].老年医学与保健,2017,23(5):389-391,395,4.基金项目
国家中医药管理局十二五重点专科建设项目(国中医药医政发[2012]2号)(沪卫中医[2012] 11号) （国中医药医政发[2012]2号）
上海市卫生中医药科研基金支撑项目(2012L033A) （2012L033A）
上海市进一步加快中医药事业发展三年行动计划(ZY3-CCCX-3-3011) （ZY3-CCCX-3-3011）
上海市中西医结合临床重大项目(ZY3-LCPT-2-2003) （ZY3-LCPT-2-2003）
上海市老年医学临床重点实验室(13dz2260700) （13dz2260700）
中医特色诊疗技术建设项目(TSJS2016001) （TSJS2016001）
上海市科学技术委员会科研计划项目(13401907000) （13401907000）
