摘要
Abstract
Objective To make a retrospective analysis on the correlation of TUBB3 and Topo Ⅱα expressions to the clinical prognosis of the elderly women with breast cancer receiving postoperative chemotherapy.Methods The clinical follow-up data of the elderly women with breast cancer treated with postoerative chemotherapy in Huashan Hospital and Jing'an Branch during the period from Jan.,2012 to June,2014 were collected and the exressions of TUBB3 and Topo Iiα in the collected pathological wax slices were analyzed;a comparative study was made to the clinical outcomes in TUBB3 group and Topo Ⅱα group.Results In total,209 elderly women with breast cancer were enrolled,with the average age of 68.3±6.4,including 67 cases of clinical stage ⅡA,74 cases of clinical stage ⅡB and 68 cases of clinical stage ⅢA;65 cases received chemotherapy based on taxanes agent,73 cases received chemotherapy based on anthracycline and 71 cases received the combined chemotheray based on the 2;at the end of the 3-year follow-up,reoccurrence,metastasis and death were found in 58 cases with the reocurrence rate of 27.75％ (43 cases) and death rate of 7.18％ (15 cases);the postive rate of TUBB3 was 48.80％ (102/209) while that of Topo Ⅱα was 48.32％ (101/209);the reocurrence rate in TUBB3 was higher (27.45％,28/102) than that in Topo Ⅱα group (14.85％,15/101) (x2=4.82,P＜0.05);the difference in death rate between TUBB3 group and Topo Hα group was of no statistical significance (9.80％ vs 4.95％) (x2=1.95,P＞0.05);the constituent ratio of remission,relapse and death in 3 chemotherapies between TUBB3 group and Topo Ⅱt group were of statistical difference (Fisherx2TUBB3 =9.55,P=0.042;Fisherx2Topo Ⅱ α=8.68,P=0.045),the ratio in TUBB3 group (62.74％,64/102) was lower than that in Topo Ⅱα group (80.20％,81/101) (x2=7.58,P＜0.05).Conclusions The expressions of TUBB3 and Topo Ⅱα are in certain correlation to the clinical outcome 3 years after postoperative chemotherapy in the elderly women with breast cancer;more attention should be paid to the effect of TUBB3 and Topo Ⅱ α expressions on the prognosis of the patients with breast cancer receiving postoperative chemotherapy.关键词
乳腺癌/3型β微管蛋白/DNA拓扑异构酶Ⅱα/预后Key words
breast cancer/TUBB3/Topo Ⅱ α/prognosis
