中南医学科学杂志2018，Vol.46Issue(1)：70-72,81,4.DOI:10.15972/j.cnki.43-1509/r.2018.01.016
早产低体重呼吸暂停患儿应用不同剂量枸橼酸咖啡因及与氨茶碱治疗疗效比较
Comparison of the effects of different doses of caffeine citrate and aminophylline in the treating premature infants with low birth weight and apnea
摘要
Abstract
To compare the effects of different doses of caffeine citrate and aminophylline in the treating premature in-fants with low birth weight and apnea.120 premature infants with low birth weight and apnea in our hospital were selected as study subjects according to different treatment methods,and they were divided into high-dose caffeine citrate,low-dose caffe-ine citrate and aminophylline groups(n=40).The clinical effect,blood gas indexes,adverse reactions and clinical outcomes were observed.Results show that the success rate of extubation in high-dose caffeine citrate group was the highest,the total times of apnea,duration of mechanical ventilation and oxygen therapy were the least and the shortest,followed by low dose group and aminophylline group.After treatment,Pa2and pH were significantly higher than those before treatment while PaC2 was significantly lower,and the changes in high dose group were the most significant,followed by low dose group and amin-ophylline group.The side effects among the three groups had significant difference.High-dose caffeine citrate has more ad-vantages over low-dose caffeine citrate and aminophylline in the treatment of premature infants with low birth weight and ap-nea.It can be used as a preferred treatment plan for premature infants with low birth weight and apnea.关键词
早产/低体重/呼吸暂停/枸橼酸咖啡因/氨茶碱Key words
premature infants/low birth weight/apnea/caffeine citrate/aminophylline分类
医药卫生引用本文复制引用
何苑棉..早产低体重呼吸暂停患儿应用不同剂量枸橼酸咖啡因及与氨茶碱治疗疗效比较[J].中南医学科学杂志,2018,46(1):70-72,81,4.基金项目
梧州市科学研究与技术开发计划项目(No.201502092). （No.201502092）
