摘要
Abstract
Objective To investigate the protective effect of telmisartan on nonalcoholic fatty liver disease and its possible mechanism.Methods A total of 30 SD rats were randomly divided into 3 groups:normal control group(NC,n =10),high fat group(group HFC,n=10)and telmisartan intervention group(group HFT,n=10).The control group was given normal diet,the high-fat group and the intervention group were given high fat diet,and the intervention group was given telmisartan to the stomach (10mg/kg/d)for 4 weeks after 12 weeks.At the end of the 16 week,blood samples were collected to detect liver function and blood lipids,while the liver tissues were harvested for pathological sections,real-time PCR,and Western blot molecular biological tests. Results Compared with group NC,the liver function and blood lipid of HFC group increased(P<0.05),the liver fatty lesion was obvious,the mRNA expression level of endoplasmic reticulum stress related protein GRP 78 and CHOP increased(P<0.05),and the protein expression of GRP78,ATF4 and CHOP increased;However,compared with group HFC,the liver function and blood lip-id level of group HFT decreased(P<0.05),the liver fat lesions improved,and the mRNA expression levels of endoplasmic reticu-lum stress related proteins and protein expression level in group HFT both decreased.Conclusion Telmisartan has protective effect on NAFLD rats,and its mechanism may be by inhibiting endoplasmic reticulum stress.关键词
非酒精性脂肪肝/替米沙坦/内质网应激/大鼠Key words
nonalcoholic fatty liver disease/telmisartan/endoplasmic reticulum stress/rats分类
医药卫生
