同济大学学报（医学版）2017，Vol.38Issue(5)：28-32,5.DOI:10.16118/j.1008-0392.2017.05.006
HMGA2在结肠癌组织中的表达及意义
Expression of HMGA2 protein in human colon cancer and its clinical significance
摘要
Abstract
Objective To investigate the expression of HMGA2 protein in colon cancer and its clinical significance.Methods HMGA2 expression was detected by immunohistochemistry in 114 samples of cancer tissues and 45 samples of pericancerous colon tissues from patients with colon cancer treated from May 2011 to December 2012.The correlation of HMGA2 expression with clinicopathological features of patients was analyzed.Results The expression rate of HMGA2 in tumor tissues (89.5％,102/114) was significant higher than that in pericancerous tissues (6.7％,3/45) (P ＜ 0.001).There was no correlation of HMGA2 expression with age,sex,tumor size,and tumor invasion depth in colon cancer.HMGA2 expression was significantly correlated with histologic grade(P ＜ 0.001),lymph node metastasis (P ＜ 0.001),distant metastasis (P ＜ 0.001) and TNM stage (P ＜ 0.014).Kaplan-Meier analysis showed significant difference in survival rates between groups with high and low HMGA2 expression (44.6％ vs.75.0％,X2 =5.736,P =0.017).Conclusion Expression of HMGA2 may be involved in the invasiveness of colon cancer playing an important role in tumor development and progression.HMGA2 expression might be a useful marker of poor prognosis in colon cancer.关键词
结肠癌/转移/高迁移率族蛋白A2Key words
colon cancer/metastasis/high mobility group AT-hook 2分类
医药卫生引用本文复制引用
朱哲,李杨,江期鑫,纪昉,高玮..HMGA2在结肠癌组织中的表达及意义[J].同济大学学报（医学版）,2017,38(5):28-32,5.基金项目
上海市浦东新区卫计委青年科技项目(PW2014B-8) （PW2014B-8）
