同济大学学报（医学版）2017，Vol.38Issue(5)：41-45,5.DOI:10.16118/j.1008-0392.2017.05.009
尿沉渣RUNX3基因甲基化检测联合B超检查在膀胱癌随访中的作用
Detection of RUNX3 gene methylation in urine sediment with transabdominal ultrasonography for follow up of non-muscle-invasive bladder cancer
摘要
Abstract
Objective To evaluate of combination of RUNX3 gene methylation detection in urine sediment with transabdominal ultrasonography for the follow up of non-muscle-invasive bladder cancer.Methods Fifty patients with primary bladder cancer,who were underwent transurethral resection (TUR) from September 2014 to February 2015 and non-muscle-invasive urothelial carcinoma was confirmed by postoperative pathology,were enrolled in this study.The patients were followed up every 3 months for 2 years after TUR.Cystoscopy,transabdominal ultrasonography and urine cytology were performed;and methylation of RUNX3 was detected in urine sediment during the follow-up.Results Among 50 cases,tumor recurrence was found in 28.For parallel test of detection of RUNX3 methylation in urine sediment with transabdominal ultrasonography,the sensitivity,specificity,Youden index and negative predictive value were 92.86％,91.62％,0.844 8 and 99.35％,respectively.Conclusion Combination of RUNX3 methylation detection in urine sediment with transabdominal ultrasonography is convenient and noninvasive in the follow up study of non-muscle-invasive bladder cancer,with high sensitivity and specificity.The negative result may indicate the extremely low possibility of recurrence of bladder cancer,which might reduce the times of cystoscopy.关键词
RUNX3/尿沉渣/膀胱癌/甲基化/随访Key words
RUNX3/urine sediment/bladder cancer/methylation/follow up分类
医药卫生引用本文复制引用
温机灵,崔铮,仇广明,王学雷,兰俊,温晓飞..尿沉渣RUNX3基因甲基化检测联合B超检查在膀胱癌随访中的作用[J].同济大学学报（医学版）,2017,38(5):41-45,5.基金项目
上海市浦东新区卫计委青年科技项目(PW2014B-9) （PW2014B-9）
