世界中医药2017，Vol.12Issue(10)：2482-2486,5.DOI:10.3969/j.issn.1673-7202.2017.10.052
中药改善原发性骨质疏松性腰背痛疗效及安全性的Meta分析
Effect and Safety of Chinese Herbal Medicine on Primary Osteoporosis with Low Back Pain:A Meta-Analysis
摘要
Abstract
Objective:To evaluate the effectiveness and safety of Chinese herbal medicine for primary osteoporosis by meta analysis.Methods:Randomized controlled clinical trials were searched from Pub Med,Cochrane,EMBASE,BioMed Central,VIP,CNKI,Sino-Med,Wanfang database.Two researchers assessed eligible data and extracted relevant elements independently according to the standards of Cochrane center.Then effective data and quality were analyzed by RevMan 5.3 Software.Results:A total of 23 randomized control clinical trials involving 1971 osteoporosis patients with pain were included.Traditional Chinese Medicine group (TCM) were compared with the control group,and significant difference between VAS(Visual Analogue Scale/Score)scores [WMD =-1.06,95％ CI (-1.49,-0.63),P ＜ 0.00001] and BMD (Bone mineral density) of lumbar spine [(Weighted Mean Difference)WMD =0.08,95％ CI (0.02,0.13),P =0.005] in short-term were found.Compared with the control group,VAS scores of short and medium term [WMD =-1.70,95％ CI (-2.18,-1.21),P ＜ 0.00001],[WMD =-0.95,95 ％ CI (-1.47,-0.43),P =0.0003] could be significantly reduced in TCM combined with control group,and the level of BMD has statistical difference in medium term.There was no statistical difference in adverse reactions between the two groups [WMD =-0.21,95％ CI (-0.43,0.01),P =0.06].Conclusion:Chinese herbal medicine could effectively alleviated low back pain from primary osteoporosis in early stage,and improved the BMD of the lumbar spine.At the same time,there was little adverse reaction.So it can be taken as a effective and safe intervention for the treatment of osteoporosis with low back pain.关键词
系统评价/Meta分析/中药煎剂/骨质疏松症/骨质疏松性腰背痛Key words
Systematic review/Meta analysis/Chinese herbal medicine/Osteoporosis/Osteoporosis with low back pain分类
医药卫生引用本文复制引用
笪巍伟,马勇,赵永见,唐德志,李晓锋,王腾腾,王拥军,施杞..中药改善原发性骨质疏松性腰背痛疗效及安全性的Meta分析[J].世界中医药,2017,12(10):2482-2486,5.基金项目
国家自然科学基金面上项目(81473701) （81473701）
上海市科委青年科技启明星计划项目(14QA1403500) （14QA1403500）
上海市科委中医重点项目(15401971700) （15401971700）
上海市卫计委新优青培养计划项目(XYQ2013085) （XYQ2013085）
上海市教委科研创新项目(14YZ051) （14YZ051）
