生物骨科材料与临床研究2018，Vol.15Issue(1)：18-22,5.DOI:10.3969/j.issn.1672-5972.2018.01.005
氨甲环酸在全膝关节置换中静脉应用的疗效对比
The efficacy comparison of tranexamic acid for controlling blood loss in total knee arthroplasty at different time
摘要
Abstract
Objective This study aimed to compare the efficacy of intravenous administration of tranexamic acid for controlling blood loss in total knee arthroplasty at different time.Methods From Jun 2015 to Jun 2017,a total of 180 patients (47 in male and 133 in female) who were planned to undergo total knee arthroplasty in our trauma center were recorded and divided into group A,B,C and D randomly.Tranexamic acid (30 mg/kg) was injected intravenously before inflation of tourniquet,after inflation of tourniquet and deflation of tourniquet in group A,B and C respectively,tranexamic acid was not applied in group D.Total blood loss (intraoperative and postoperative blood loss),reduction ofhaemaglobin,blood transfusion rate,blood transfusion volume and accidence of deep vein thrombosis were recorded and analyzed.Results Compared with group B and C,there were significant reduction of blood loss,haemaglobin and blood transfusion rate (P＜0.05).Besides,there was no significant difference between group B and C with superior efficacy than group D.Conclusion Intravenous administration oftranexamic acid before inflation of tourniquet was superior in terms of blood loss,haemaglobin and blood transfusion rate.关键词
氨甲环酸/静脉应用/全膝关节置换/失血量/使用时间Key words
Tranexamic acid/Intravenous administration/Total knee arthroplasty/Blood loss/Different time分类
医药卫生引用本文复制引用
虞宵,章鸿,繆烨,徐人杰,张向鑫,陈广祥..氨甲环酸在全膝关节置换中静脉应用的疗效对比[J].生物骨科材料与临床研究,2018,15(1):18-22,5.基金项目
2017年江苏省高层次卫生人才“六个一工程”拔尖人才项目(LGY2017008) （LGY2017008）
2016年苏州市临床重点病种诊疗技术专项项目(LCZX201618) （LCZX201618）
