山西医科大学学报2018，Vol.49Issue(2)：132-135,4.DOI:10.13753/j.issn.1007-6611.2018.02.007
HIF-1α在喉鳞癌组织芯片中的表达及临床意义
Expression and clinical significance of HIF-1 in laryngeal squamous cell carcinoma using tissue microarray
摘要
Abstract
Objective To investigate the expression of hypoxia inducible factor(HIF)-1α in laryngeal squamous cell carcinomas,and its correlation with clinicopathological features and prognosis using tissue microarray. Methods A total of 138 specimens of laryngeal squamous cell carcinoma and 32 normal laryngeal mucosa were used to detect the expression of HIF-1α by immunohistochemistry. Re-sults The positive rate of HIF-1α protein was significantly higher in laryngeal squamous cell carcinomas tissues than that in normal la-ryngeal mucosa.HIF-1α protein expression level was correlated with TNM stage and lymph node metastasis(P<0.05). HIF-1α protein expression was not correlated with the tumor site,age and gender(P>0.05). Conclusion HIF-1α may be involved in the occurrence and progress of laryngeal squamous cell carcinomas. The expression of HIF-1α can be used as a reference for the biological behavior of laryngeal squamous cell carcinoma.关键词
低氧诱导因子-1α/喉鳞癌/组织芯片Key words
laryngeal squamous cell carcinoma/tissue microarray分类
医药卫生引用本文复制引用
冯彦,孟亚萍,雒红霞,白玮,张森,王斌全..HIF-1α在喉鳞癌组织芯片中的表达及临床意义[J].山西医科大学学报,2018,49(2):132-135,4.基金项目
山西省基础研究计划青年科技研究基金资助项目(2014021037-2) （2014021037-2）
山西医科大学第一医院青年基金资助项目(YQ1310) （YQ1310）
山西医科大学校博士启动基金资助项目(03201628) （03201628）
