实用医学杂志2017，Vol.33Issue(22)：3737-3741,5.DOI:10.3969/j.issn.1006-5725.2017.22.015
择时用药对非杓型高血压患者血压昼夜节律的影响
Effect of prescription medication on circadian rhythm of blood pressure in non-dipper hypertensive patients
摘要
Abstract
Objective To explore the effect of combined prescription medication on non-dipper hyperten sive patients.Methods 76 patients with non-dipper hypertensive patients were randomly divided into group A (n =38) and group B (n =38).Telmisartan tablets,hydrochlorothiazide tablets and levamlodipine tablets were given in two groups.Patients in group A take oral medicine at 8 pm,and patients in group B take oral medicine at 8 pm.The levels of plasma angiotensin Ⅱ,plasma endothelin-1 (ET-1),plasma renin,matrix metalloproteinase9 (MMP-9) and Chemerin protein were observed in both groups.Results After treatment,24 h SBP,dSBP and nSBP in group B were significantly lower than those in group A (P ＜ 0.05).The dipper value of group B was significantly higher than that of group A (P ＜ 0.05).The diversion rate of group B was significantly higher than that of group A (P ＜ 0.01).The levels of renin,angiotensin Ⅱ,ET-1,MMP-9 and Chemerin in group B were significantly lower than those in group A at 6 AM and 0:00 (P ＜ 0.05).The degree of change in group B at 0:00 was more significant than that in 6:00 AM (P ＜ 0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05).Conclusion The efficacy of telmisartan,hydrochlorothiazide combined with levamlodipine in patients with non-dipper hypertensive patients performs better if patients take medicine at 8 pm other than at 8 pm.关键词
非杓型高血压/替米沙坦/血压昼夜节律/基质金属蛋白酶9/Chemerin蛋白Key words
non-dipper type hypertension/Telmisartan/blood pressure circadian rhythm/matrix metalloproteinase 9/Chemerin protein引用本文复制引用
张中潇,杨春,杨国文,卢亚莉..择时用药对非杓型高血压患者血压昼夜节律的影响[J].实用医学杂志,2017,33(22):3737-3741,5.基金项目
重庆卫计委资助项目(编号:2015MSXM084) （编号:2015MSXM084）
