实用医学杂志2017，Vol.33Issue(22)：3769-3772,4.DOI:10.3969/j.issn.1006-5725.2017.22.023
EHD2在非小细胞肺癌中的表达及其临床意义
EHD2 expression and clinical significance in non-small cell lung cancer
摘要
Abstract
Objective We studied the EHD2 expression level in NSCLC and its association with clinicopathological features and prognosis.Methods The EHD2 expression level in NSCLC was measured by Western blot in 4 pairs fresh tissues and immunohistochemistry on 91 parffin-embedded slices.These experiments were used to explore the relationship of EHD2 and Ki-67 in the clinical parameters,as well as the relationship with EHD2 and prognosis.Results Western blot showed EHD2 expression level was low in 4 pairs NSCLC tissues.The results by immunohistochemistry showed that the expression of EHD2 was higher in well-differentiated NSCLC tissues than that in poor-differentiated tissues,which was opposite to the Ki-67 expression.Statistical methods revealed that EHD2 protein in NSCLC was significantly correlated with histological grade,pTNM staging,tumor size,lymph node metastasis as well as Ki-67.Low EHD2 expression was correlated with poor prognosis.Conclusions The abnormal expression of EHD2 might be closely related to the initiation and progress of NSCLC.EHD2 might be an indicator of the prognosis of NSCLC,which could be a potential target for NSCLC therapy.关键词
非小细胞肺癌/EHD2/Ki-67/预后Key words
non-small cell lung cancer/EHD2/Ki-67/prognosis引用本文复制引用
吕丽婷,刘益飞,刘军,盖领,茅国新..EHD2在非小细胞肺癌中的表达及其临床意义[J].实用医学杂志,2017,33(22):3769-3772,4.基金项目
国家自然科学基金青年基金(编号:81602010) （编号:81602010）
南通市级科技计划(编号:MS22016071) （编号:MS22016071）
