实用医学杂志2017，Vol.33Issue(22)：3819-3821,3.DOI:10.3969/j.issn.1006-5725.2017.22.036
脑梗死患者同型半胱氨酸与血脂相关性及其诊断价值
Correlation study between Hcy and blood lipid level and its diagnostic value in patients with cerebral infarction
摘要
Abstract
Objective To investigate the correlation between Hcy and blood lipid level and its diagnostic value in patients with cerebral infarction.Methods 218 patients with cerebral infarction were divided into the cerebral infarction group and no cercbral infarction group,based on the diagnosis results of head CT or MRI,and 60 healthy individuals were used as the control group.The levels of serum TC,TG,HDL-c,LDL-c and serum Hcy were determined in each group.The level of serum Hcy was used as a diagnostic-test and the criterion of cerebral infarction which was diagnosed by using head CT or MRI was used as a gold standard.Meanwhile,the sensibility,specificity,predictive value and likelihood ratio of Hcy were measured in patients with and without cerebral infarction.Results Levels of TC and Hcywere significantly elevated (P ＜ 0.01),but HDL-c level was significantly decreased in patients with and without cerebral infarction compared with the healthy people (P ＜ 0.05).Hcy level was shown negatively correlated with HDL-c (r =-0.144,P ＜ 0.05).The sensibility and specificity of Hcy in both two groups of patients with and without cerebral infarction were 42.20％ and 54.13％,the positive predictive value and negative predictive value of Hcy were 47.92％ and 48.36％,the positive likelihood ratio and negative likelihood ratio of Hcy were 0.92 and 1.07,respectively.Conclusion Hcy and blood lipid have definite correlation,but Hcy has low diagnostic value for cerebral infarction and may not be used as a biological marker for the cerebral infarction diagnosis.关键词
脑梗死/同型半胱氨酸/血脂/相关性/诊断试验Key words
cerebral infarction/homocysteine/lipid/correlation/diagnostic test引用本文复制引用
方兴,江颖,欧俐羽,梁武健,曹桢斌..脑梗死患者同型半胱氨酸与血脂相关性及其诊断价值[J].实用医学杂志,2017,33(22):3819-3821,3.基金项目
广西卫生厅项目(编号:Z2014125) （编号:Z2014125）
广西高校科学技术研究项目(编号:KY2015YB148) （编号:KY2015YB148）
