实用医学杂志2018，Vol.34Issue(2)：281-284,4.DOI:10.3969/j.issn.1006-5725.2018.02.031
不同剂量右美托咪定联合乌司他丁对肺叶切除术患者肺损伤的保护作用
The protective effect of dexmedetomidine atdifferent doses combined with ulinastatin in lung resection pa-tients with one lung ventilation
摘要
Abstract
Objective To observe the protective effect of dexmedetomidine(Dex)at different doses com-bined with ulinastatin in lung resection patients with one lung ventilation. Methods 80 patients having undergone unilateral lung resection were divided into four groups randomly:control group(C group)and groups Dex 1-3,20 cases in each group.One lung ventilation(OLV)was used in all the groups during operation.The patients in groups Dex 1-3 were treated with 0.5,1.0,2.0 μg/kg combined with ulinastatin,and the C group with amount of normal sa-line instead.The comparisons were done among the four groups in terms of SOD,L-6,IL-10,serum malondialde-hyde(MDA)concentration at 5 min after endotracheal intubation(T0),30 min(T1),60 min(T2),120 min (T3)as well as the levels of FVC,FEVl and FEVl/FVC at 24 h,48 h and 72 h after surgery. Results In the groups C and Dex 1,SOD decreased at T1-4 and IL-6,MDA and IL-10 at T2-4 rose.SOD decreased at T2-4 in groups Dex 2-3 and MDA,IL-6 and IL-10 rose.Compared with group C,the levels of SOD and IL-10 at T2-4 in groups Dex 1-2 and at T1-4 in group Dex 3 rose. In groups Dex 1-3,postoperative FVC,FEVl and FEVl/FVC rose.Compared with group Dex 1 or 2 respectively,SOD and IL-10 at T2-4 in group Dex 3 significantly rose,but MDA and IL-6 significantly declined;FVC,FEVl and FEVl/FVC significantly rose 48 h and 72 h after surgery (P<0.05). Conclusion Dex combined with ulinastatin has a protective effect for patients with one lung ventila-tion after lung resection,with the best-suggested dose of 1.0 μg/kg.关键词
右美托咪定/乌司他丁/单肺通气/肺损伤Key words
dexmedetomidine/ulinastatin/one lung ventilation/lung injury引用本文复制引用
周桥灵,赵伟成,廖美娟,梁桦,王汉兵,刘洪珍,杨承祥..不同剂量右美托咪定联合乌司他丁对肺叶切除术患者肺损伤的保护作用[J].实用医学杂志,2018,34(2):281-284,4.基金项目
广东省临床重点专科建设资金资助项目(编号:粤卫文(2011)144) （编号:粤卫文(2011）
广东省科技厅资助项目(编号:2014A020212003) （编号:2014A020212003）
佛山市医学类科技攻关项目(编号:2014AB00306) （编号:2014AB00306）
