实用医学杂志2018，Vol.34Issue(2)：285-288,4.DOI:10.3969/j.issn.1006-5725.2018.02.032
依托泊苷胶囊治疗晚期转移性乳腺癌的疗效
Efficacy of etoposide capsule on metastatic breast cancer
曾惠爱 1闫敏 1律慧敏 1张梦玮 1牛李敏 1刘真真 1崔树德1
作者信息
- 1. 郑州大学附属肿瘤医院乳腺科 郑州450008
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of etoposide capsule on metastatic breast cancer. Methods Forty-five advanced breast cancer patients treated with oral etoposide during Feb.1,2012 and Oct.31, 2016 in our department were enrolled in our study,with their general data,median number of treatment lines, treatment effect,common adverse reaction collected. Such indexes of objective response rate,rate of clinical benefit,disease control rate,progression free survival time were anlayzed. Results All patients received median five lines of etoposide capsule therapy. The objective response rate(ORR,CR + PR)was 6.7% and the clinical benefit rate(CBR,CR+PR+SD≥6.0 months)was 26.7% and the disease control rate(DCR,CR+PR+SD) was 68.9%.The median progression free survival time(PFS)was 4.0 months(95% CI:2.3~5.6).The main toxic-ities were grade 1-2 neutropenia(37.8%),grade 3-4 neutropenia(6.7%).Conclusion Etoposide capsule could be an option with efficacy and safety for metastatic breast cancer.关键词
依托泊苷胶囊/转移性乳腺癌/疗效Key words
etoposide capsule/metastatic breast/efficacy引用本文复制引用
曾惠爱,闫敏,律慧敏,张梦玮,牛李敏,刘真真,崔树德..依托泊苷胶囊治疗晚期转移性乳腺癌的疗效[J].实用医学杂志,2018,34(2):285-288,4.
