实用医学杂志2018，Vol.34Issue(2)：305-308,4.DOI:10.3969/j.issn.1006-5725.2018.02.037
B细胞特异性激活蛋白PAX-5在间变性大细胞淋巴瘤中的异常表达及意义
Expression and significance of BSAP(PAX-5)in anaplastic large cell lymphoma
摘要
Abstract
Objective To investigate the expression of PAX-5 in anaplastic large cell lymphoma, discuss the value and pitfalls of PAX-5 in the diagnosis and differential diagnosis of lymphomas. Methods A total of 269 T lymphomas were studied retrospectively.PAX-5 positive anaplastic large cell lymphoma was confirmed by immo-munohistochemistry and gene rearrangement analysis. Literature review was performed and the clinicopathological features were discussed.Results Two cases of anaplastic large cell lymphoma were found with aberrant expression of PAX-5. Conclusions As a relatively specific B cell marker, PAX-5 can also express in anaplastic large cell lymphoma. In the diagnosis of lymphomas, especially the differential diagnosis between classical Hodgkin lympho-ma and Anaplastic large-cell lymphoma, diagnosis errors should be avoided by interpreting PAX-5 immunohisto-chemistry in the context of clinical features, morphology, a panel of B- and T-lineage-associated antibodies, and gene rearrangement analysis.关键词
间变性大细胞淋巴瘤/PAX-5Key words
anaplastic large cell lymphoma/PAX-5引用本文复制引用
李学锋,朱梅刚,丁向东,冯晓冬,张志魁,徐炜..B细胞特异性激活蛋白PAX-5在间变性大细胞淋巴瘤中的异常表达及意义[J].实用医学杂志,2018,34(2):305-308,4.基金项目
广州市科技计划项目(编号:201604046001) （编号:201604046001）
