实用医学杂志2018，Vol.34Issue(2)：316-319,4.DOI:10.3969/j.issn.1006-5725.2018.02.040
康艾注射液联合单药化疗治疗老年晚期非小细胞肺癌的有效性和安全性
Effectiveness and safety of Kang′ai injection combined with single agent chemotherapy in treatment of el-derly patients with advanced NSCLC
陈汉锐 1田华琴 2陈志明 3黄学武 1郑心婷 2陈学彰 1林丽珠1
作者信息
- 1. 广州中医药大学第一附属医院肿瘤中心 广州510405
- 2. 佛山市中医院肿瘤科 广东佛山528000
- 3. 汕头大学医学院附属肿瘤医院中西医结合科 广东汕头515031
- 折叠
摘要
Abstract
Objective To observe the effectiveness and safety of Kang′ai injection combined with docetaxel or gemcitabine chemotherapy in treatment of elderly patients with advanced non-small cell lung cancer(NSCLC). Methods A multi-center,randomized and parallel control study was carried out in 150 elderly patients with ad-vanced NSCLC treated in 3 hospitals during the period from June 2013 to August 2014.The patients were randomly divided into platinum-based group(platinum-based doublet chemotherapy)and Kang′ai group(Kang′ai injection combined with single agent chemotherapy). The clinical efficacy,quality of life and adverse reactions were ob-served and compared between the two groups. Results There was no significant difference in the disease control rate between the two groups group(79.66% vs 81.82%)(χ2=0.101,P=0.751)while the effective rate of Kang′ai group was significantly higher than that of platinum-based group(30.51% vs 14.29%)(χ2=5.240,P=0.022). The effective rate of clinical symptom relief in Kang′ai group after treatment was significantly higher than that in platinum-based group(69.49% vs 48.05%)(χ2=6.278,P=0.012),and the increase rate of PS score in Kang′ai group after the treatment was also significantly higher than that in platinum-based group(18.64% vs 3.90%)(χ2=7.868,P=0.005).There was no significant difference in quality of life between two groups(P>0.05).The quali-ty of life score of Kang′ai group was significantly higher than that of platinum-based group at the second course of treatment(P<0.05).The incidence of adverse reactions in Kang′ai group was significantly lower than that in the platinum-based group(47.46% vs 71.42%)(χ2= 8.070,P < 0.05). Conclusion Kang′ai injection combined with single agent chemotherapy can effectively relieve clinical symptoms and reduce the tumor size in elderly patients with advanced NSCLC,with high safety.关键词
康艾注射液/单药化疗/晚期非小细胞肺癌Key words
Kang′ai injection/single agent chemotherapy/advanced non-small cell lung cancer引用本文复制引用
陈汉锐,田华琴,陈志明,黄学武,郑心婷,陈学彰,林丽珠..康艾注射液联合单药化疗治疗老年晚期非小细胞肺癌的有效性和安全性[J].实用医学杂志,2018,34(2):316-319,4.
