天津中医药大学学报2018，Vol.37Issue(1)：49-52,4.DOI:10.11656/j.issn.1673-9043.2018.01.12
白及与川乌配伍对大鼠卡拉胶模型血流速度和镇痛效果的影响
The effect of Radix Aconiti and Rhizoma Bletillae separately and combined on carrageenan-induced mechanical hyperalgesia on rat
摘要
Abstract
[Objective]To determine the effect of of Radix Aconiti and Rhizoma Bletillae separately and combined on carrageenan-induced mechanical hyperalgesia on rat.[Methods]Thirty-four male SD rats were randomly divided into 5 groups:Normal group(n=4),Model group(n=6),Radix Aconiti group(n=8),Rhizoma Bletillae group(n=8)and Radix Aconiti-Rhizoma Bletillae combined group(n=8)0.1 mL carrageenan solution was injected into the left hind paw of all rats except the normal group. The 5 groups were separately dosed with saline, saline, Radix Aconiti extraction(2.25 mg/kg),Rhizoma Bletillae extraction(2.25 mg/kg)and Radix Aconiti-Rhizoma Bletillae extractions combined(2.25 mg/kg+2.25 mg/kg)1 h post the carrageenan injection.Mechanical hyperalgesia was measured by the paw-pressure test(analgesimeter,Ugo Basile,Italy),Blood flow was measured by Laser Doppler Flowmetry at 1 h and 3 h post the test reagent dosed.[Results]Single dosing of Radix Aconiti extraction(2.25 mg/kg)has significant analgesic effects. Single dosing of Rhizoma Bletillae extraction(2.25 mg/kg)can decreased the blood flow of the inflammation paw.Radix Aconiti-Rhizoma Bletillae extractions combined(2.25 mg/kg+2.25 mg/kg)has analgesic effects and can decreased the blood flow of the inflammation paw. [Conclusion]Radix Aconiti extraction has analgesic effects and Rhizoma Bletillae extraction can decreased the blood flow. When they were dosed combined, don't influenced the other.关键词
卡拉胶/镇痛/激光多普勒Key words
carrageenan/analgesia/laser doppler flowmetry分类
医药卫生引用本文复制引用
庞坦,李小锦,庄朋伟..白及与川乌配伍对大鼠卡拉胶模型血流速度和镇痛效果的影响[J].天津中医药大学学报,2018,37(1):49-52,4.基金项目
国家重点基础研究发展计划(973计划)(2011C B505300,2011CB505302). （973计划）
