新生儿局灶性白质损伤的MRI研究现状及其核心问题的思考
Overview and considerations on MRI research of neonatal punctate white matter lesions
摘要
Abstract
The number of preterm neonates appears to remain high in China in recent years.These subjects are vulnerable to pathogenic factors and have brain lesions easily.Punctate white matter lesions(PWML)are very common(the incidence＞20%).The degeneration in the brain associated with PWML is harmful to the outcomes and hard to be detected.Early diagnosis and prediction of PWML are focuses for pediatric researchers.This paper describes the change patterns and spatial distributions associated with PWML.The factors of individual differences and development during the diagnosis and prognosis are discussed as well.Finally,the paper points out the core problems in developmental brain template construction,individualized diagnosis,and early prediction.关键词
新生儿局灶性白质损伤/脑功能与结构/病变类型/个体化诊断/早期预测Key words
neonatal punctate white matter lesion/brain function and structure/degeneration pattern/individualized diagnosis/early prediction分类
医药卫生引用本文复制引用
杨健,李贤军..新生儿局灶性白质损伤的MRI研究现状及其核心问题的思考[J].西安交通大学学报（医学版）,2018,39(2):153-159,7.基金项目
国家重点研发计划(No.2016YFC0100300) （No.2016YFC0100300）
国家自然科学基金面上项目(No.81771810,81471631,81171317) （No.81771810,81471631,81171317）
教育部新世纪优秀人才支持计划(No.NCET-11-0438) （No.NCET-11-0438）
西安交通大学第一附属医院重点临床专项(No.XJTUIAF-CRF-2015-004)、青年创新基金(No.2011YK.19,2017QN-09)资助Supported by the National Key Research and Development Program of China(No.2016YFC0100300) （No.XJTUIAF-CRF-2015-004）
the National Natural Science Foundation of China(No.81771810,81471631,81171317) （No.81771810,81471631,81171317）
the New Century Excellent Talent Support Plan of the Ministry of Education,China(No.NCET-11-0438) （No.NCET-11-0438）
the Key Clinical Research Award(No.XJTUIAF-CRF-2015-004)and the Youth Innovation Fund of the First Affiliated Hospital of Xi'an Jiaotong University(No.2011YK.19,2017QN-09) （No.XJTUIAF-CRF-2015-004）
