磁共振扩散张量成像多参量评估早产与足月新生儿脑白质发育
Evaluation of the development on the preterm and term neonatal brain white matter based on metrics derived from diffusion tensor imaging
摘要
Abstract
Objective To explore developmental states on the preterm and term neonatal brain white matter based on the co-variation of metrics derived from diffusion tensor imaging(DTI).Methods This work enrolled 66 neonates,consisting of 33 preterm(21 males and 12 females;gestational age:30.143-36.286 weeks)and 33 full-term neonates(22 males and 11 females;gestational age:37.000 -41.429 weeks).DTI derived metrics included axial diffusivity(AD),radial diffusivity(RD),and fractional anisotropy(FA).Spearman's rank correlation between metrics and postmenstrual age was analyzed in the preterm and term neonates.Developmental states were evaluated according to the method proposed by Dubois:fiber organization was associated with increased AD, decreased RD and increased FA;pre-myelination was related to decreased AD,decreased RD and unchanged/increased FA;myelination was revealed by unchanged AD,decreased RD and increased FA.Mann-Whitney U test was used to compare DTI metrics between the preterm and term neonates.Results According to the method proposed by Dubois,posterior limb of internal capsule and corpus callosum underwent myelination in the preterm-neonate period.Cerebral peduncle started myelination in the term-neonate period.Superior corona radiate,inferior fronto-occipital fasciculus and external capsule underwent pre-myelination on preterm and term neonates.FA values were higher in term neonates than those in preterm neonates in all the selected regions(P＜0.05).AD and RD values were lower in term neonates than those in preterm neonates in the selected regions except for cerebral peduncle(P＜0.05).Conclusion Changes in DTI metrics and the method of Dubois can be used to quantitatively evaluate developmental states of the neonatal brain white matter.The changes coincided with DTI variations associated with pre-myelination and myelination.White matter development is delayed in preterm neonates compared with term neonates.关键词
新生儿/脑白质/发育评估/扩散张量成像/早产儿Key words
neonate/brain white matter/evaluation of development/diffusion tensor imaging/preterm neonate分类
医药卫生引用本文复制引用
李贤军,刘哲,孙亲利,王苗苗,刘聪聪,侯欣,刘黎明,杨健..磁共振扩散张量成像多参量评估早产与足月新生儿脑白质发育[J].西安交通大学学报（医学版）,2018,39(2):168-173,6.基金项目
国家重点研发计划资助(No.2016YFC0100300) （No.2016YFC0100300）
国家自然科学基金面上项目资助(No.81471631和81171317) （No.81471631和81171317）
教育部新世纪优秀人才支持计划(No.NCET-11-0438) （No.NCET-11-0438）
陕西省自然科学基金青年项目资助(No.2017JQ8005)以及西安交通大学第一附属医院青年创新基金资助(No.2011YK.19,2017QN-09)Supported by the National Key Research and Development Program of China(No.2016YFC0100300) （No.2017JQ8005）
the National Natural Science Foundation of China(No.81471631,81171317) （No.81471631,81171317）
the New Century Excellent Talent Support Plan of the Ministry of Education,China(No.NCET-11-0438) （No.NCET-11-0438）
Shaanxi Provincial Natural Science Foundation for Youths of China(No.2017JQ8005) （No.2017JQ8005）
and the Youth Innovation Fund of the First Affiliated Hospital of Xi'an Jiaotong University(No.2011YK.19,2017QN-09) （No.2011YK.19,2017QN-09）
