西安交通大学学报（医学版）2018，Vol.39Issue(2)：174-178,193,6.DOI:10.7652/jdyxb201802004
脑瘫儿童深部灰质损伤MRI分级系统的临床价值比较
Comparison of the clinical value of MRI classification system of deep gray matter injury in children with cerebral palsy
摘要
Abstract
Objective To investigate the reliability of MRI classification and clinical significance of deep gray matter injury(DGMI)in children with cerebral palsy(CP).Methods We made a retrospective assessment of 14 children with gross motor function classification system(GMFCS),manual ability classification system(MACS)and MRI classification system of deep gray matter injury.Based on T2WI,two radiologists worked independently and graded MRI pictures according to three-grading system and four-grading system.To evaluate the reliability of different grading systems,intra-observer and inter-observer agreements were tested by Kappa test.Spearman correlation analysis was performed to analyze the MRI classification system with GMFCS and MACS.Results The Kappa value of the intro-observer and inter-observe agreement of three-grading system was 0.873 and 0.873,respectively (P＜0.001).The Kappa value of the intro-observer and inter-observe agreement of four-grading system was 0.901 and 0.611(P＜0.001).Three-grading system had no significant correlation with GMFCS(r=0.053,P＞0.05)or MACS(r=0.128,P＞0.05).Four-grading system had a significant positive correlation with GMFCS(r=0.605, P＜0.05)and MACS(r=0.779,P＜0.05).Conclusion In the two grading systems,four-grading system is a more repeatable approach for detecting deep gray matter,gross motor function and manual function injuries in children with cerebral palsy.关键词
脑瘫/深部灰质/磁共振成像/粗大运动功能分级系统/手功能分级系统Key words
cerebral palsy/deep gray matter/magnetic resonance imaging(MRI)/gross motor function classi-fication system(GMFCS)/manual ability classification system(MACS)分类
医药卫生引用本文复制引用
刘衡,孙亲利,马敬伟,王辉,杨健,王苗苗,王小玗,赵慧芳,吴亮,蒋昊翔,刘聪聪,李贤军,金超..脑瘫儿童深部灰质损伤MRI分级系统的临床价值比较[J].西安交通大学学报（医学版）,2018,39(2):174-178,193,6.基金项目
国家重点研发计划(No.2016YFC0100300) （No.2016YFC0100300）
国家自然科学基金面上项目(No.81471631,81171317) （No.81471631,81171317）
2011年教育部"新世纪优秀人才支持计划"(No.NCET-11-0438) （No.NCET-11-0438）
西安交通大学第一附属医院青年创新基金(No.2011YK.19)Supported by the National Key Research and Development Program of China(No.2016YFC0100300) （No.2011YK.19）
the National Natural Science Foundation of China(No.81471631,81171317) （No.81471631,81171317）
the 2011 New Century Excellent Talent Support Plan of the Ministry of Education,China(No.NCET-11-0438) （No.NCET-11-0438）
and the Youth Innovation Fund of the First Affiliated Hospital of Xi'an Jiaotong University(No.2011YK.19) （No.2011YK.19）
