西安交通大学学报（医学版）2018，Vol.39Issue(2)：266-270,5.DOI:10.7652/jdyxb201802022
基于基因组学探讨糖尿病肾病的发病原因及其与心血管疾病的关系
Mechanism of diabetic kidney disease and its relationship with cardiovascular disease based on genomics
摘要
Abstract
Objective To provide the basis for early diagnosis and clinical treatment for diabetic kidney disease(DKD)and cardiovascular disease by analyzing the causes of DKD and the relationship between them. Methods Microarray gene chip data from the glomerulus in DKD were downloaded from GEO Database.The gene expression profile,gene function,protein-protein interaction network,gene and signal pathway co-expression network of control and DKD groups were analyzed and the key node genes between the two groups were selected by R,QOE,GCBI,STRING and Genclip.Results The gene expression profile of glomerular tissue in DKD patients was significantly altered.Compared with control group,there were 844 differentially expressed genes in DKD patients.One protein-protein interaction network with the core of TNNT 2 occurred among top 20 differentially expressed genes.Differentially expressed genes were mainly related to inflammatory and stress responses,as well as to MAPK signal pathway.Conclusion The cause of DKD is mainly related to inflammatory and stress responses, which are also related to cardiovascular disease.关键词
糖尿病肾病/心血管疾病/差异表达基因/转录谱Key words
diabetic kidney disease/cardiovascular disease/differentially expressed gene/transcriptional spec-trum分类
医药卫生引用本文复制引用
任晓梅,杨景锋,刘启玲,辛宝,张荣强..基于基因组学探讨糖尿病肾病的发病原因及其与心血管疾病的关系[J].西安交通大学学报（医学版）,2018,39(2):266-270,5.基金项目
陕西省科技厅自然科学基础研究计划项目(No.2016JM8031) （No.2016JM8031）
陕西省中医管理局中医药科研基金项目(No.13-LC062)Supported by the Natural Science Research Foundation of Science and Technology Department of Shaanxi Province(No.2016JM8031)and Chinese Medicine Foundation of Shaanxi Administration of Traditional Chinese Medicine(No.13-LC062) （No.13-LC062）
