厦门大学学报（自然科学版）2017，Vol.56Issue(6)：809-816,8.DOI:10.6043/j.issn.0438-0479.201703043
聚肽/聚己内酯共混电纺纳米纤维的制备以及高效Thiol-Yne光化学表面改性
Fabrication of Electrospinning Polypeptide/Polycaprolactone Blend Nanofibers and Their Highly Effective Surface Modification by Thiol-Yne Photochemistry
摘要
Abstract
Synthetic polypeptides are unique biomaterials in the field of drug/gene delivery,tissue engineering and regenerative medicine.But electrospinning nanofibers used for tissue engineering are hard to be fabricated as a result of the rigid backbone of polypeptides caused by their α-helix and β-sheet conformations.In addition,the subsequent surface modifications of electrospinning nanofibers probably destroy the nanofibers.Thus,the fabrication and application of the electrospinning nanofibers of synthetic polypeptides are limited.In this work,electrospinning polypeptide/polycaprolactone (PCL) blend nanofibers were fabricated and then undergone surface modification by thiol-yne click chemistry,a fast non-destructive and highly effective access.Results of scanning electron microscope(SEM) and Fourier transform-infrared (FT-IR) spectroscopy showed that diameter and orientation of the nanofibers were determined by the polypeptide contents,and the surface modification did not destroy the surface morphology.X-ray photoelectron spectroscopy(XPS) confirmed the amine modification of the surface by the gentle thiol-yne method.关键词
聚肽/聚己内酯/电纺/纳米纤维/巯-炔/表面改性Key words
polypeptide/polycaprolactone (PCL)/electrospinning/nanofibers/thiol-yne/surface modification分类
化学化工引用本文复制引用
易玲,罗伟昂,叶国东,黄玉刚..聚肽/聚己内酯共混电纺纳米纤维的制备以及高效Thiol-Yne光化学表面改性[J].厦门大学学报（自然科学版）,2017,56(6):809-816,8.基金项目
国家自然科学基金(51403043,51103123) （51403043,51103123）
福建省阻燃与防火材料技术重大研发平台项目(2014H2006) （2014H2006）
