医药导报2018，Vol.37Issue(3)：315-318,4.DOI:10.3870/j.issn.1004-0781.2018.03.010
碳青霉烯类抗菌药物使用强度与4种常见革兰阴性病原菌耐药性的相关性
Correlation Analysis between Carbapenem Consumption and Resistance to Carbapenems Among Gram Negative Bacteria Isolates
摘要
Abstract
Objective To evaluate the correlation between carbapenem consumption and resistance to carbapenems among the frequent gram-negative bacteria and provide the basis for rational use of drugs. Methods Retrospective review was used to calculate the DDDs of carbapenems(impenem and meropenem) per 100 persons per day from the year of 2004 to 2016 and resistant rate of the frequent gram-negative bacteria(Acinetobacter baumannii,Pseudomonas aeruginosa,Klebsiella pneumoniae,and Escherich-ia coli).The correlation of drug usage and resistance were analyzed by SPSS 17.0 software. Results The study demonstrated that carbapenem usage was strongly correlated with imipenem and meropenem-resistant Acinetobacter baumannii,Klebsiella pneumoniae, while has no significant correlation with Pseudomonas aeruginosa,Escherichia coli. Conclusion The growing problem of gram-negative bacteria resistant to carbapenems was strongly related to the high consumption of carbapenems.It also suggested that opti-mum antibiotic use was necessary to alleviate the threat posed by resistant microorganisms at the hospital level.关键词
抗菌药物,碳青霉烯类/使用强度,抗菌药物/病原菌,常见/耐药性Key words
Antimicrobial agents,carbapenem/Use density,antibiotics/Gram-negative bacteria,Frequent/Drug resist-ance分类
医药卫生引用本文复制引用
姚屹瑾,方洁,孙景勇,时国朝..碳青霉烯类抗菌药物使用强度与4种常见革兰阴性病原菌耐药性的相关性[J].医药导报,2018,37(3):315-318,4.基金项目
国家自然科学基金面上项目(81470216) （81470216）
