中国动脉硬化杂志2018，Vol.26Issue(1)：1-6,6.
细胞焦亡在动脉粥样硬化中的作用
Role of pyroptosis in atherosclerosis
摘要
Abstract
Pyroptosis is a pro-inflammatory form of death,which depends on the enzymatic activation of inflammatory proteases that belong to the family of cysteine-dependent aspartate-specific protease (Caspases).It is characterized by pore formation,plasma membrane rupture,cellular contents and pro-inflammatory mediators entering extracellular space,leading to inflammation and cell death.The inflammasome-activated Caspase-1 plays an important role in the induction of pyroptosis.Recent reports showed that pyroptosis plays an important role in atherosclerosis.This review article describes the pyroptosis and its mechanism,the progresses of study on the pyroptosis of macrophage and endothelial cell,and the relationship between pyroptosis and atherosclerosis.关键词
细胞焦亡/动脉粥样硬化/巨噬细胞/内皮细胞Key words
Pyroptosis/Atherosclerosis/Macrophages/Endothelial cells分类
医药卫生引用本文复制引用
李秀珍,黄孝天,符民桂..细胞焦亡在动脉粥样硬化中的作用[J].中国动脉硬化杂志,2018,26(1):1-6,6.基金项目
美国心脏协会基金资助(17AIREA33660073) （17AIREA33660073）
