中国动脉硬化杂志2018，Vol.26Issue(1)：46-50,5.
多学科协作模式改变缺血性卒中超早期重组组织型纤溶酶原激活剂静脉溶栓的预后
Multiple disciplinary team model improves the effect of rt-PA intravenous thrombolytic therapy in patients with acute ischemic stroke
摘要
Abstract
Aim To investigate the effect on implementation of standard procedure of recombinant tissue-type plasminogen activator (rt-PA) intravenous thrombolysis in patients with acute ischemic stroke (AIS).Methods One hundred and sixty-four AIS patients were enrolled in this study.Thirty-four cases were assigned into the before-implementation group and one hundred and thirty into the after-implementation group.Door-to-needle time (DNT),NIHSS scores and modified Rankin scale (mRS) scores of the patients in the two groups were analyzed.The durations of every step in the treatment procedure were statistically compared between the two groups.Results The average DNT in the after-implementation group [(81.31 ± 15.13) min] was significantly shorter than that in the before-implementation group [(111.76 ±24.84) min] (P＜0.001).The discharge NIHSS scores declined remarkably compared with baseline NIHSS scores in both two groups,and the difference had statistical significance (P＜0.01).The discharge NIHSS scores and mRS scores in the after-implementation group was significantly lower than that in the before-implementation group (P＜0.01).The time interval between arrival at emergent department and beginning CT scan in the two groups was not statistically significant.The time interval between arrival at emergent department and starting the procedure by telephone,consulting chief resident physician and signing the informed consents were significantly shorter in the after-implementation group (P＜0.01).Conclusion Implementing MDT model of rt-PA intravenous thrombolysis standarding procedure contributes to shortening the DNT and improving the therapeutic effects.关键词
多学科协作模式/重组组织型纤溶酶原激活剂/静脉溶栓/急性缺血性卒中Key words
Multiple disciplinary team/Recombinant tissue-type plasminogen activator/Intravenous thrombolysis/Acute ischemic stroke分类
医药卫生引用本文复制引用
秦冰,林银瑶,陆正齐..多学科协作模式改变缺血性卒中超早期重组组织型纤溶酶原激活剂静脉溶栓的预后[J].中国动脉硬化杂志,2018,26(1):46-50,5.基金项目
广东省医学科学技术研究基金项目(A2016059) （A2016059）
国家自然科学基金项目(81701167) （81701167）
广东省自然科学基金项目(2017A030310360) （2017A030310360）
