中国动脉硬化杂志2018，Vol.26Issue(1)：60-64,5.
血压对非动脉粥样硬化中年人颈动脉形态、血流动力学的影响
Effect of blood pressure on the carotid artery morphology and hemodynamics of middle-aged people without atherosclerosis
摘要
Abstract
Aim To analyze the characteristics of carotid artery morphology and hemodynamics before and after atherosclerosis (As) in subjects with different blood pressure levels,and to provide evidence for the early prevention and treatment of atherosclerosis in different blood pressure groups.Methods 308 subjects (age range 40 ～ 65 years,mean age 52.2±4.7 years) were screened and divided into normal blood pressure group,normal high blood pressure group,grade Ⅰ hypertension group,exclusion of major cardiovascular diseases,such as atherosclerosis,coronary heart disease,etc.The carotid intima-media (IMT),resistance index (RI),pulse index (PI),peak systolic velocity (PSV) and internal diameter were measured by GE vivid 7 Color Doppler,blood flow wall shear force (WSS) was calculated and four blood lipids were detected by blood biochemical analyzer.Results Age,heart rate,body mass index (BMI),total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDLC),high density lipoprotein cholesterol (HDLC) in the three groups did not show significant difference,BMI did not reach the standard of obesity,the basic information in the three groups had no significant difference.Systolic blood pressure and diastolic blood pressure in hypertension group were significantly higher than those in normal high blood pressure group and normal blood pressure group (P＜0.05).In normal high blood pressure group,systolic blood pressure and diastolic blood pressure were significantly higher than those in normal blood pressure group (P＜0.05),and the subjects were successfully grouped according to blood pressure level.PSV in normal high blood pressure group and grade I hypertension group was higher than that in normal blood pressure group,PSV in normal high blood pressure group was higher than that in grade I hypertension group,PSV,PI and RI had no signifcant difference in the three groups.WSS in normal high blood pressure group and grade I hypertension group was significantly lower than that in normal blood pressure group (P＜0.05).The diameter of carotid artery in normal high blood pressure group and grade Ⅰ hypertension group was significantly higher than that in normal blood pressure group (P＜0.05),and IMT had no significant difference between the two groups.Conclusion The carotid artery diameter increased and WSS decreased in the two groups of non atherosclerotic middle-aged people with elevated blood pressure.WSS in non atherosclerotic people with different blood pressure is nore sensitive than PI and RI.关键词
动脉粥样硬化/中年人/血压/颈动脉形态/血流动力学Key words
Atherosclerosis/Middle-aged people/Blood pressure/Carotid morphology/Hemodynamics分类
医药卫生引用本文复制引用
王文荣,熊开宇,何辉,吕媛媛,俞梦晨..血压对非动脉粥样硬化中年人颈动脉形态、血流动力学的影响[J].中国动脉硬化杂志,2018,26(1):60-64,5.基金项目
中央高校基本科研业务费专项资金资助项目(2015ZD005 （）
2017YB020) （）
