中国动脉硬化杂志2018，Vol.26Issue(1)：77-84,8.
促红细胞生成素对急性心肌梗死经皮冠状动脉成形术后疗效的Meta分析及系统评价
Administration of erythropoietin in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a systematic review and Meta-analysis
摘要
Abstract
Aim This meta-analysis was to systematically assess the efficacy and safety of erythropoietin (EPO) for patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI).Methods Eight online databases were investigated (CNKI,CBM,Wanfang,VIP,PubMed,Embase,Cochrane Library,Web of Science),then randomized clinical trials (RCT) comparing the efficacy of EPO versus non-EPO in patients with AMI after PCI published before January 2017 were included.Data analysis was carried out using RevMan software(V.5.3).Results 14 RCT (enrolling 2044 patients) were included in the review.Literatures with low risk bias showed,in the case of improving left ventricular ejection fraction (LVEF),lefi ventricular end-systolic volume (LVESV),lefi ventricular enddiastolic volume (LVEDV) and infarct size,EPO and non-EPO treatment had no distinction.Literatures with high risk bias showed,EPO could significantly improve LVEF,reduce the LVESV and infarct size,no significant difference of EPO was found on LVEDV.High doses of EPO had no effect on vascular events;low doses can reduce the incidence of vascular events.Conclusion The use of EPO in patients with AMI may not improve left ventricular function (LVEF,LVEDV,LVESV) and infarct size after PCI,and low-dose may improve the incidence of vascular events.关键词
急性心肌梗死/促红细胞生成素/经皮冠状动脉成形术/Meta分析Key words
Acute myocardial infarction/Erythropoietin/Percutaneous coronary intervenion/Meta-analysis分类
医药卫生引用本文复制引用
卢芬萍,苏宁,征宗梅,朱明明,申毓军,施洪飞..促红细胞生成素对急性心肌梗死经皮冠状动脉成形术后疗效的Meta分析及系统评价[J].中国动脉硬化杂志,2018,26(1):77-84,8.基金项目
国家自然科学基金面上项目(81574044) （81574044）
