中国肺癌杂志2018，Vol.21Issue(2)：67-75,9.DOI:10.3779/j.issn.1009-3419.2018.02.01
中国肺癌低剂量螺旋CT筛查指南(2018年版)
China National Lung Cancer Screening Guideline with Low-dose Computed Tomography (2018 version)
摘要
Abstract
Background and objective Lung cancer is the leading cause of cancer-related death in China. The results from a randomized controlled trial using annual low-dose computed tomography (LDCT) in specific high-risk groups demonstrated a 20% reduction in lung cancer mortality. The aim of tihs study is to establish the China National lung cancer screening guidelines for clinical practice. Methods The China lung cancer early detection and treatment expert group (CLCEDTEG) established the China National Lung Cancer Screening Guideline with multidisciplinary representation including 4 thoracic surgeons, 4 thoracic radiologists, 2 medical oncologists, 2 pulmonologists, 2 pathologist, and 2 epidemiologist. Members have engaged in interdisciplinary collaborations regarding lung cancer screening and clinical care of patients with at risk for lung cancer. The expert group reviewed the literature, including screening trials in the United States and Europe and China, and discussed local best clinical practices in the China. A consensus-based guidelines, China National Lung Cancer Screening Guideline (CNLCSG), was recommended by CLCEDTEG appointed by the National Health and Family Planning Commission, based on results of the National Lung Screening Trial, systematic review of evidence related to LDCT screening, and protocol of lung cancer screening program conducted in rural China. Results Annual lung cancer screening with LDCT is recommended for high risk individuals aged 50-74 years who have at least a 20 pack-year smoking history and who currently smoke or have quit within the past five years. Individualized decision making should be conducted before LDCT screening. LDCT screen-ing also represents an opportunity to educate patients as to the health risks of smoking; thus, education should be inte-grated into the screening process in order to assist smoking cessation. Conclusion A lung cancer screening guideline is recommended for the high-risk population in China. Additional research , including LDCT combined with biomarkers, is needed to optimize the approach to low-dose CT screening in the future.关键词
肺肿瘤/指南/筛查/LDCT/高危人群Key words
Lung neoplasms/Guideline/Screening/LDCT/High risk population引用本文复制引用
周清华,郑向鹏,步宏,李印,韦森,陈良安,胡成平,石远凯,孙燕,范亚光,王颖,乔友林,王贵齐,黄云超,王新允,吴宁,张国桢..中国肺癌低剂量螺旋CT筛查指南(2018年版)[J].中国肺癌杂志,2018,21(2):67-75,9.基金项目
本研究受国家重大研发计划项目(No.2016YFE0103400)资助 This study was partly supported by the grant from the National Key Research and Development Project of Chi-na(to Qinghua ZHOU)(No.2016YFE0103400). （No.2016YFE0103400）
