中国肺癌杂志2018，Vol.21Issue(2)：116-120,5.DOI:10.3779/j.issn.1009-3419.2018.02.05
FGFR作为肺鳞癌潜在治疗靶点的研究进展
Progress on the Study of Targeting FGFR in Squamous Non-small Cell Lung Cancer
摘要
Abstract
Squamous cell lung cancer (SqCLC) is a unique clinical and histologic category of non-small cell lung cancer (NSCLC). Most of patients with SqCLC tend to be older, typically at advanced stage, associated with smoking and have more complications. With progress of targeted therapy of lung cancer, we identified several potential actionable genetic abnormalities such as FGFR. Several FGFR inhibitors have been approved for clinical use in different cancers. And some of these agents are currently under investigation in clinical trials for SqCLC. This article summarizes the current knowledge about FGFR aberrations, the relative inhibitors in development and clinical data in SqCLC.关键词
FGFR/肺鳞癌/治疗靶点Key words
FGFR/SqCLC/Targeting引用本文复制引用
董明,李彤,陈军..FGFR作为肺鳞癌潜在治疗靶点的研究进展[J].中国肺癌杂志,2018,21(2):116-120,5.基金项目
本文受国家自然科学基金项目(No.81600073)资助 This paper was supported by the grant from National Natural Science Foundation(to Ming DONG)(No.81600073). （No.81600073）
